Table II.
CircRNAs involved in intervertebral disc degeneration.
| Author, year | CircRNAs | Expression | Cell type | Signal pathways | Investigated processes | (Refs.) |
|---|---|---|---|---|---|---|
| Guo et al, 2018 | circ-GRB10 | Downregulated | Human nucleus pulposus cell | circ-GRB10/miR-328-5p/ERBB2 | Apoptosis | (192) |
| Cheng et al, 2018 | circ-VMA21 | Downregulated | Human and rat nucleus pulposus cell | circ-VMA21/miR-200c/XIAP | Apoptosis and inflammation | (125) |
| Wang et al, 2018 | circ-4099 | Upregulated | Human nucleus pulposus cell | circ-4099/miR-616-5p/Sox9 | ECM synthesis and inflammation | (184) |
ECM, extracellular matrix; miR, microRNA; circRNA, circular RNA; XIAP, X-linked inhibitor of apoptosis protein.