Figure 1.

miR-150 antagomiR treatment enhances memory and learning abilities in VD model rats. (A) Timeline of rat experiments (n=12 per group). (B) Escape latency of rats during the first 5 days using the MWM test. (C) Representative movement tracking of rats on the 5th day as measured using the MWM test. (D) miR-150 expression levels in the brain tissues of rats were determined via reverse transcription-quantitative PCR. Experiments were repeated three times. Data are presented as the mean ± standard deviation. Two-way mixed ANOVA followed by Tukey's post hoc test was used to analyze the data presented (B). One-way ANOVA followed by Tukey's post hoc test was used to analyze the data presented (D). **P<0.01 vs. control; ^##P<0.01 vs. antagomiR NC. miR, microRNA; VD, vascular dementia; MWM, Morris water maze; NC, negative control; D, day.