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. 2021 Feb 18;16:92. doi: 10.1186/s13023-020-01656-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Total GRAF Score by ATI Cohort. The total risk score (Gaucher Risk Assessment for Fracture [GRAF] score) and the individual risk factor estimates from the Cox proportional hazards regression for first fracture (any type) in adulthood after treatment initiation are plotted by each age at treatment initiation (ATI) cohort in panels A through C. Panel A includes the forest plots for the < 18 years ATI cohort. Panel B includes the forest plots for the ≥ 18 to < 50 years ATI cohort. Panel C includes the forest plots for the ≥ 50 years ATI cohort. Panels D through F are the corresponding forest plots of the GRAF score and individual risk factor estimates for the secondary spinal fractures analyses. CI = confidence interval; Dx = diagnosis; NA = not applicable; Tx = treatment

Fig. 1 — Total GRAF Score by ATI Cohort. The total risk score (Gaucher Risk Assessment for Fracture [GRAF] score) and the individual risk factor estimates from the Cox proportional hazards regression for first fracture (any type) in adulthood after treatment initiation are plotted by each age at treatment initiation (ATI) cohort in panels A through C. Panel A includes the forest plots for the < 18 years ATI cohort. Panel B includes the forest plots for the ≥ 18 to < 50 years ATI cohort. Panel C includes the forest plots for the ≥ 50 years ATI cohort. Panels D through F are the corresponding forest plots of the GRAF score and individual risk factor estimates for the secondary spinal fractures analyses. CI = confidence interval; Dx = diagnosis; NA = not applicable; Tx = treatment