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Rapid depletion and slow compensation of SUMO1 protein are key factors for HIF-1α protein degradation. (A) SUMO1, ubiquitin and VEGF protein expression levels were investigated via western blotting. (B) Protein expression levels were normalized to those of β-actin. Data are presented as the mean ± standard deviation. n=3. *P<0.05 vs. normoxia. SUMO1, small ubiquitin-related modifier 1; HIF, hypoxia inducible factor; VEGF, vascular endothelial growth factor.
