Table 6.

Plasma protein binding and whole blood partitioning of (r)-SJ733 and (r)-SJ311

Species	(r)-SJ733		(r)-SJ311
	% bounda	B/P ratio	% bounda	B/P ratio
Mouse	95.7 ± 0.6		93.7 ± 0.7
Rat	90.0 ± 1.7		91.0 ± 0.1
Dog	88.3 ± 3.1		90.0 ± 1.0
Human	94.3 ± 0.6	0.72 ± 0.02b	95.3 ± 0.6

^aValues of protein binding are average of all high, medium and low concentrations (20, 4, 0.8 µM), all of which were similar. Data are presented as mean ± SD (n = 3)

^bValue reported previously [16]