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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Heart Rhythm. 2020 Sep 12;18(2):250–260. doi: 10.1016/j.hrthm.2020.09.007

Figure 2.

Figure 2

Ca2+ sparks recorded from wild-type (WT) and mutant hiPSC-CMs. A–D: Representative time courses of normalized Ca2+ sparks from the selected regions (different colors) in WT and 3 homozygous mutants. E: Histogram and distribution curves show the spark duration measured at half-maximum amplitude. **P < .01 vs WT. Spark durations in F2483I and R420Q cells are significantly longer than those in Q4201R hiPSC-CMs (P < .01). F: Spark frequency of WT and mutant cells. *P < .05, R420Q vs F2483I by 1-way analysis of variance. Part of the WT and F2483I-hom data are published previously.17