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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Heart Rhythm. 2020 Sep 12;18(2):250–260. doi: 10.1016/j.hrthm.2020.09.007

Figure 5.

Figure 5

L-type Ca2+ current(ICa), fractional Ca2+ release, and calcium-induced calcium release (CICR) gain. A–D: Representative traces of ICa and ICa-induced Ca2+ release (left panels), ICa tail currents and their induced Ca2+ release (middle panels), and caffeine-induced Ca2+ release and INCX (right panels) from WT and 3 homozygous mutant hiPSC-CMs. E: Quantified ICa density (bottom panel) and ICa-induced Ca2+ release (top panel) in WT and mutant cells. F: Fractional Ca2+ release (top panel) and CICR gain (bottom panel) in each group. *P < .05, **P < .01 by 1-way analysis of variance.