Table 1.
DEGs identified in KEGG pathway: MAPK-signaling. Differential expression indicates the average log2-fold change in RNA-Seq transcript levels from three independent experiments at each sampling period: D7 vs D0, D13 vs D7, D18 v D13, and D28 v D18. The p-values were ≤ 0.001. Negative log2-fold change corresponds to gene downregulation and the positive values indicate gene activation
| MAPK-signaling pathway | |||
|---|---|---|---|
| Gene ID | Description | Differential expression | Time |
| CACNA1B | voltage-dependent calcium channel N type alpha-1B | −1.834598101 | D0-D7 |
| CACNA2D1 | voltage-dependent calcium channel alpha-2/delta-1 | −5.013073193 | D0-D7 |
| CACNB3 | voltage-dependent calcium channel beta-3 | 1.96153735 | D0-D7 |
| CACNG5 | voltage-dependent calcium channel gamma-5 | − 3.611690367 | D0-D7 |
| CACNG7 | voltage-dependent calcium channel gamma-7 | −2.217348209 | D0-D7 |
| CACNG8 | voltage-dependent calcium channel gamma-8 | −3.68477059 | D0-D7 |
| FGF2 | fibroblast growth factor 2 | −1.519463128 | D0-D7 |
| KITLG | KIT ligand | 2.167299479 | D0-D7 |
| NTRK2 | neurotrophic tyrosine kinase receptor type 2 | 8.559108654 | D0-D7 |
| KIT | proto-oncogene tyrosine-protein kinase Kit | 2.471526791 | D0-D7 |
| FLT1 | MS-like tyrosine kinase 1 | −6.287270931 | D0-D7 |
| KDR | kinase insert domain protein receptor | −5.882467261 | D0-D7 |
| TGFB2 | transforming growth factor beta-2 | 2.871123317 | D0-D7 |
| RASGRP2 | RAS guanyl-releasing protein 2 | −3.455335916 | D0-D7 |
| GNG12 | guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | −2.188972021 | D0-D7 |
| MYC | Myc proto-oncogene protein | −2.952930394 | D0-D7 |
| MECOM | ecotropic virus integration site 1 protein | 3.315425714 | D0-D7 |
| PPM1B | protein phosphatase 1B | −1.591315588 | D0-D7 |
| ERBB4 | receptor tyrosine-protein kinase erbB-4 | 4.531919812 | D7-D13 |
| CACNA1B | voltage-dependent calcium channel N type alpha-1B | 1.88048051 | D7-D13 |
| CACNA2D3 | voltage-dependent calcium channel alpha-2/delta-3 | 3.068907158 | D7-D13 |
| NTRK1 | neurotrophic tyrosine kinase receptor type 1 | 4.469959879 | D7-D13 |
| TGFB2 | transforming growth factor beta-2 | 2.803343326 | D7-D13 |
| KIT | proto-oncogene tyrosine-protein kinase Kit | −2.467841933 | D13-D18 |
| CACNG5 | voltage-dependent calcium channel gamma-5 | 4.656489914 | D13-D18 |
| FGFR4 | fibroblast growth factor receptor 4 | −3.26316459 | D13-D18 |
| CACNA1E | voltage-dependent calcium channel R type alpha-1E | 3.425325465 | D18-D28 |
| CACNG2 | voltage-dependent calcium channel gamma-2 | 3.474133324 | D18-D28 |
| CACNG8 | voltage-dependent calcium channel gamma-8 | 3.189789 | D18-D28 |
| KITLG | KIT ligand | 2.028343818 | D18-D28 |
| EGFR | epidermal growth factor receptor | −2.084730311 | D18-D28 |
| FGFR1 | fibroblast growth factor receptor 1 | −2.081183963 | D18-D28 |
| FGFR2 | fibroblast growth factor receptor 2 | −3.256153332 | D18-D28 |
| FGFR3 | fibroblast growth factor receptor 3 | −5.009604609 | D18-D28 |
| KDR | kinase insert domain protein receptor | 3.118215378 | D18-D28 |
| IL1RAP | interleukin 1 receptor accessory protein | 3.502622162 | D18-D28 |
| PRKCB | classical protein kinase C beta type | 1.642454101 | D18-D28 |
| PTPRR | receptor-type tyrosine-protein phosphatase R | 2.837257876 | D18-D28 |
| PTPN5 | tyrosine-protein phosphatase non-receptor type 5 | 2.472116702 | D18-D28 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | −1.628879059 | D18-D28 |
| CDC25B | M-phase inducer phosphatase 2 | −3.052843516 | D18-D28 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 1.972512785 | D18-D28 |