Table 2.
DEGs identified in KEGG pathway: Calcium signaling. Differential expression indicates the average log2-fold change in RNA-Seq transcript levels from three independent experiments at each sampling period: D7 vs D0, D13 vs D7, D18 v D13, and D28 v D18. The p-values were ≤ 0.001. Negative log2-fold change corresponds to gene downregulation and the positive values indicate gene activation
| Calcium signaling pathway | |||
|---|---|---|---|
| Gene ID | Description | Differential expression | Time |
| HTR7 | 5-hydroxytryptamine receptor 7 | −5.492892685 | D0-D7 |
| CACNA1B | voltage-dependent calcium channel N type alpha-1B | −1.834598101 | D0-D7 |
| CXCR4 | C-X-C chemokine receptor type 4 | 4.604478969 | D0-D7 |
| ADCY2 | adenylate cyclase 2 | −3.460253861 | D0-D7 |
| STIM1 | stromal interaction molecule 1 | 1.834422349 | D0-D7 |
| VDAC1 | voltage-dependent anion channel protein 1 | −1.32731076 | D0-D7 |
| GNA14 | guanine nucleotide-binding protein subunit alpha-14 | −5.014275635 | D0-D7 |
| TRDN | Triadin | −4.320486512 | D0-D7 |
| RYR2 | ryanodine receptor 2 | −4.07053211 | D0-D7 |
| RYR3 | ryanodine receptor 3 | 1.71133494 | D0-D7 |
| ITPR2 | inositol 1,4,5-triphosphate receptor type 2 | −3.699823272 | D0-D7 |
| ITPR3 | inositol 1,4,5-triphosphate receptor type 3 | −2.406497059 | D0-D7 |
| ERBB4 | receptor tyrosine-protein kinase erbB-4 | 4.531919812 | D7-D13 |
| CACNA1B | voltage-dependent calcium channel N type alpha-1B | 1.88048051 | D13-D18 |
| CACNA1E | voltage-dependent calcium channel R type alpha-1E | 3.425325465 | D13-D18 |
| GRIN2A | glutamate receptor ionotropic, NMDA 2A | 2.854753149 | D13-D18 |
| P2RX3 | P2X purinoceptor 3 | 2.552456853 | D13-D18 |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV | 1.41910402 | D13-D18 |
| CHRM3 | muscarinic acetylcholine receptor M3 | 3.978819163 | D18-D28 |
| HTR7 | 5-hydroxytryptamine receptor 7 | 3.808433488 | D18-D28 |
| GRIN1 | glutamate receptor ionotropic, NMDA 1 | 3.726336735 | D18-D28 |
| GRIN2D | glutamate receptor ionotropic, NMDA 2D | 2.087932817 | D18-D28 |
| CHRM2 | muscarinic acetylcholine receptor M2 | 3.383752478 | D18-D28 |
| ADRA1A | adrenergic receptor alpha-1A | 4.207285974 | D18-D28 |
| TACR3 | tachykinin receptor 3 | 2.111829478 | D18-D28 |
| GRM1 | metabotropic glutamate receptor 1 | 3.134222868 | D18-D28 |
| EGFR | epidermal growth factor receptor | −2.084730311 | D18-D28 |
| GNAL | guanine nucleotide-binding protein G(olf) subunit alpha | 1.685044809 | D18-D28 |
| ADCY2 | adenylate cyclase 2 | 3.240853085 | D18-D28 |
| STIM2 | stromal interaction molecule 2 | 1.158068159 | D18-D28 |
| RYR2 | ryanodine receptor 2 | 4.896050853 | D18-D28 |
| PRKCB | classical protein kinase C beta type | 1.642454101 | D18-D28 |