Table 3.
DEGs identified in KEGG pathway: Neuroactive ligand-receptor interaction. Differential expression indicates the average log2-fold change in RNA-Seq transcript levels from three independent experiments at each sampling period: D7 vs D0, D13 vs D7, D18 v D13, and D28 v D18. The p-values were ≤ 0.001. Negative log2-fold change corresponds to gene downregulation and the positive values indicate gene activation
| Neuroactive ligand-receptor interaction | |||
|---|---|---|---|
| Gene ID | Description | Differential expression | Time |
| APLNR | apelin receptor | 4.656030708 | D0-D7 |
| NMUR2 | neuromedin U receptor 2 | 8.490690944 | D0-D7 |
| F2 | coagulation factor II (thrombin) | 2.589060962 | D0-D7 |
| CNR1 | cannabinoid receptor 1 | 2.81817017 | D0-D7 |
| S1PR1 | sphingosine 1-phosphate receptor 1 | 5.38497247 | D0-D7 |
| GRM4 | metabotropic glutamate receptor 4 | −3.861684955 | D0-D7 |
| GRIN2B | glutamate receptor ionotropic, NMDA 2B | −2.895136106 | D0-D7 |
| CHRNA3 | nicotinic acetylcholine receptor alpha-3 | 2.7938378 | D0-D7 |
| HTR7 | 5-hydroxytryptamine receptor 7 | −5.492892685 | D0-D7 |
| CHRNB4 | nicotinic acetylcholine receptor beta-4 | 4.925250798 | D0-D7 |
| GRIA1 | glutamate receptor 1 | 3.01762919 | D0-D7 |
| GRIA4 | glutamate receptor 4 | −2.647220311 | D0-D7 |
| GRIK1 | glutamate receptor, ionotropic 42ainite 1 | 2.276415318 | D0-D7 |
| GRIK4 | glutamate receptor, ionotropic 42ainite 4 | −3.020412525 | D0-D7 |
| GRID2 | glutamate receptor delta-2 subunit | −5.40793957 | D0-D7 |
| GLRA2 | glycine receptor alpha-2 | 1.792820308 | D0-D7 |
| GLRB | glycine receptor beta | 3.452103236 | D0-D7 |
| NR3C1 | glucocorticoid receptor | −2.452514385 | D0-D7 |
| GHR | growth hormone receptor | 2.976564346 | D0-D7 |
| CNR1 | cannabinoid receptor 1 | 2.626395057 | D7-D13 |
| NR3C1 | glucocorticoid receptor | 3.341402421 | D7-D13 |
| GRIN2A | glutamate receptor ionotropic, NMDA 2A | 2.854753149 | D13-D18 |
| CHRNA4 | nicotinic acetylcholine receptor alpha-4 | 2.830329136 | D13-D18 |
| P2RX3 | P2X purinoceptor 3 | 2.552456853 | D13-D18 |
| GRIA2 | glutamate receptor 2 | 3.273675604 | D13-D18 |
| GRIA4 | glutamate receptor 4 | 2.416455621 | D13-D18 |
| ADCYAP1R1 | pituitary adenylate cyclase-activating polypeptide type I receptor | 2.615605165 | D13-D18 |
| CHRM2 | muscarinic acetylcholine receptor M2 | 3.383752478 | D18-D28 |
| CHRM3 | muscarinic acetylcholine receptor M3 | 3.978819163 | D18-D28 |
| ADRA1A | adrenergic receptor alpha-1A | 4.207285974 | D18-D28 |
| DRD2 | dopamine receptor D2 | −2.728065758 | D18-D28 |
| HTR7 | 5-hydroxytryptamine receptor 7 | 3.808433488 | D18-D28 |
| NMU | neuromedin U | −2.62455439 | D18-D28 |
| NPY5R | neuropeptide Y receptor type 5 | 3.804748523 | D18-D28 |
| HCRTR2 | hypocretin (orexin) receptor 2 | 3.98239527 | D18-D28 |
| SSTR1 | somatostatin receptor 1 | 6.807432954 | D18-D28 |
| TAC1 | tachykinin 1 | 3.869735499 | D18-D28 |
| TACR3 | tachykinin receptor 3 | 2.111829478 | D18-D28 |
| PTGER4 | prostaglandin E receptor 4 | 2.824782168 | D18-D28 |
| GPR50 | G protein-coupled receptor 50 | 4.747091061 | D18-D28 |
| LPAR1 | lysophosphatidic acid receptor 1 | 1.500777066 | D18-D28 |
| S1PR1 | sphingosine 1-phosphate receptor 1 | 2.506524278 | D18-D28 |
| ADCYAP1R1 | pituitary adenylate cyclase-activating polypeptide type I receptor | −2.231972171 | D18-D28 |
| GRM1 | metabotropic glutamate receptor 1 | 3.134222868 | D18-D28 |
| GRIN1 | glutamate receptor ionotropic, NMDA 1 | 3.726336735 | D18-D28 |
| GRIN2D | glutamate receptor ionotropic, NMDA 2D | 2.087932817 | D18-D28 |
| GRIN3A | glutamate receptor ionotropic, NMDA 3A | 2.914543821 | D18-D28 |
| CHRNA3 | nicotinic acetylcholine receptor alpha-3 | −2.670435709 | D18-D28 |
| GRIA2 | glutamate receptor 2 | 2.698334339 | D18-D28 |
| GRIA4 | glutamate receptor 4 | 1.923861676 | D18-D28 |
| GRID2 | glutamate receptor delta-2 subunit | 4.217720694 | D18-D28 |
| GRIN2B | glutamate receptor ionotropic, NMDA 2B | 4.109294839 | D18-D28 |
| GLRA3 | glycine receptor alpha-3 | 5.577349539 | D18-D28 |
| GLRB | glycine receptor beta | 1.392250382 | D18-D28 |