Table 3.

HRs for risk of outcomes according to quartiles of baseline TyG index

Outcomes	TyG index				P value for trend
	Quartile 1 (3.61–8.18)	Quartile 2 (8.18–8.57)	Quartile 3 (8.57–9.05)	Quartile 4 (9.05–12.50)
Stroke
Case, n (%)	922 (3.78)	1139 (4.67)	1403 (5.75)	1658 (6.79)
Incidence, per 1000 person-y	3.60	4.48	5.54	6.59
Model 1	Reference	1.20 (1.10–1.31)	1.46 (1.35–1.59)	1.79 (1.65–1.93)	< 0.001
Model 2	Reference	1.14 (1.05–1.25)	1.34 (1.23–1.46)	1.58 (1.45–1.72)	< 0.001
Model 3	Reference	1.08 (0.99–1.18)	1.22 (1.12–1.33)	1.32 (1.21–1.44)	< 0.001
Ischemic stroke
Case, n (%)	725 (2.97)	944 (3.87)	1183 (4.85)	1425 (5.84)
Incidence, per 1000 person-y	2.82	3.70	4.65	5.64
Model 1	Reference	1.26 (1.15–1.39)	1.57 (1.43–1.72)	1.96 (1.79–2.14)	< 0.001
Model 2	Reference	1.21 (1.10–1.33)	1.44 (1.31–1.58)	1.73 (1.58–1.90)	< 0.001
Model 3	Reference	1.14 (1.03–1.26)	1.31 (1.19–1.44)	1.45 (1.31–1.59)	< 0.001
Intracerebral hemorrhage
Case, n (%)	190 (0.78)	193 (0.79)	244 (1.00)	253 (1.04)
Incidence, per 1000 person-y	0.73	0.75	0.95	0.98
Model 1	Reference	0.98 (0.80–1.20)	1.22 (1.01–1.48)	1.30 (1.07–1.56)	< 0.001
Model 2	Reference	0.93 (0.76–1.14)	1.13 (0.93–1.37)	1.16 (0.95–1.41)	0.04
Model 3	Reference	0.89 (0.73–1.09)	1.03 (0.85–1.25)	0.97 (0.79–1.18)	0.84

Model 1, adjusted for age and sex

Model 2, adjusted for variables in model 1 plus level of education, income, smoking, alcohol abuse, physical activity, and body mass index

Model 3, adjusted for variables in model 2 plus systolic blood pressure, diastolic blood pressure, history of myocardial infarction, hypertension, diabetes mellitus, and dyslipidemia, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-sensitive C-reactive protein, antidiabetic drugs, lipid-lowering drugs and antihypertensive drugs

TyG indicates triglyceride-glucose