Table 4.

HRs for risk of outcomes according to quartiles of updated cumulative average TyG index

Outcomes	TyG index				P value for trend
	Quartile 1 (4.67–8.31)	Quartile 2 (8.31–8.65)	Quartile 3 (8.65–9.06)	Quartile 4 (9.06–12.20)
Stroke
Case, n (%)	1056 (4.33)	1157 (4.74)	1291 (5.29)	1618 (6.63)
Incidence, per 1000 person-y	4.18	4.54	5.06	6.42
Model 1	Reference	1.12 (1.03–1.22)	1.27 (1.17–1.37)	1.71 (1.58–1.85)	< 0.001
Model 2	Reference	1.06 (0.98–1.16)	1.16 (1.06–1.26)	1.50 (1.38–1.63)	< 0.001
Model 3	Reference	1.01 (0.93–1.10)	1.05 (0.96–1.14)	1.25 (1.15–1.36)	< 0.001
Ischemic stroke
Case, n (%)	830 (3.40)	963 (3.94)	1089 (4.46)	1395 (5.71)
Incidence, per 1000 person-y	3.27	3.76	4.25	5.51
Model 1	Reference	1.19 (1.08–1.31)	1.37 (1.25–1.50)	1.89 (1.73–2.06)	< 0.001
Model 2	Reference	1.13 (1.03–1.24)	1.25 (1.14–1.37)	1.66 (1.51–1.81)	< 0.001
Model 3	Reference	1.07 (0.98–1.18)	1.13 (1.03–1.24)	1.39 (1.27–1.52)	< 0.001
Intracerebral hemorrhage
Case, n (%)	219 (0.90)	203 (0.83)	214 (0.88)	244 (1.00)
Incidence, per 1000 person-y	0.85	0.78	0.83	0.95
Model 1	Reference	0.94 (0.78–1.14)	1.00 (0.83–1.21)	1.20 (1.00–1.44)	0.04
Model 2	Reference	0.89 (0.73–1.08)	0.92 (0.76–1.11)	1.06 (0.88–1.29)	0.45
Model 3	Reference	0.85 (0.70–1.03)	0.83 (0.68–1.00)	0.89 (0.73–1.08)	0.26

Model 1, adjusted for age and sex

Model 2, adjusted for variables in model 1 plus level of education, income, smoking, alcohol abuse, physical activity, and body mass index

Model 3, adjusted for variables in model 2 plus systolic blood pressure, diastolic blood pressure, a history of myocardial infarction, hypertension, diabetes mellitus, and dyslipidemia, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-sensitive C-reactive protein, antidiabetic drugs, lipid-lowering drugs and antihypertensive drugs. TyG indicates triglyceride-glucose