Table 1.

Correlation between T lymphocyte (CD3+) and regulatory T cell (FOXP3+) infiltration and clinicopathological features in primary breast cancer

Variable	N (%)	CD3 infiltration				R	P	N (%)	FOXP3 infiltration				R	P
		0	1	2	3				0	1	2	3
All	175 (100)	37	70	48	20			176 (100)	67	66	39	4
Age
< 50	79 (45.1)	15	36	22	6	0,04	0,60	81 (46.0)	30	29	19	3	-0,05	0,54
≥ 50	96 (54.9)	22	34	26	14			95 (54.0)	37	37	20	1
Tumor size
≤ 20 mm	73 (41.7)	17	28	20	8	0,03	0,71	73 (41.5)	30	27	15	1	0,06	0,42
> 20 mm	102 (58.2)	20	42	28	12			102 (58.0)	37	38	24	3
Nodal metastasis
-	57 (32.6)	13	22	17	5	0,03	0,74	57 (32.4)	16	26	13	2	-0,10	0,18
+	114 (65.1)	24	45	31	14			116 (65.9)	48	40	26	2
Ki67
-	108 (61.7)	28	47	23	10	0,21	0,01	109 (61.9)	52	38	18	1	0,33	0,000
+	59 (33.7)	9	19	21	10			58 (33.0)	10	25	20	3
NHG
Grade 1/2	62 (35.4)	12	31	16	3	0,06	0,43	64 (36.4)	27	24	13	0	0,06	0,48
Grade 3	91 (52.0)	22	32	24	13			91 (51.7)	34	36	17	4
ER
-	33 (18.9)	6	9	10	8	-0,16	0,04	32 (18.2)	8	11	12	1	-0,17	0,03
+	138 (78.9)	31	59	36	12			139 (79.0)	56	54	26	3
PR
-	74 (42.3)	18	23	20	13	-0,08	0,29	72 (40.9)	25	27	19	1	-0,07	0,39
+	96 (54.9)	19	45	26	6			98 (55.7)	39	38	18	3
Luminal A	59 (33.7)	14	29	12	4	-0,17	0,03	60 (34.1)	32	20	7	1	-0,30	0,000
Luminal B	72 (41.1)	15	26	23	8	0,04	0,65	72 (40.9)	18	33	19	2	0,17	0,03
HER2	9 (5.1)	2	2	1	4	0,10	0,20	8 (4.5)	2	5	1	0	0,00	0,96
TN	22 (12.6)	3	7	9	3	0,11	0,16	22 (12.5)	5	6	10	1	0,18	0,02

Abbreviations: N number of patients included in analysis, R correlation coefficient, Ki67 proliferation marker, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor, TN triple negative. Spearman correlation, two-tailed P value. Bold indicates P value < 0.05