Table 3.

Cox regression analyses for breast cancer-specific survival. Primary tumor

Variable	HR	(95% CI)	P value	HR	(95% CI)	P value
	Univariable			Multivariable
Tumor size
≤20 vs >20	1,49	(1.14 - 1.96)	0,004	1,41	(0.94 - 2.12)	0,094
NHG
1, 2 vs 3	1,61	(1.14 - 2.28)	0,007	1,65	(1.07 - 2.53)	0,023
Nodal metastasis
- vs +	1,51	(1.13 - 2.02)	0,006	2,01	(1.30 - 3.10)	0,002
ER
- vs +	0,42	(0.27 - 0.63)	0,000	0,57	(0.34 - 0.97)	0,038
CD3
low vs high	2,34	(1.40 - 3.91)	0,001	1,39	(0.77 - 2.50)	0,28
FOXP3
low vs high	1,64	(1.39 - 2.37)	0,008	1,72	(1.14 - 2.59)	0,010

Abbreviations: HR hazard ratio, CI confidential interval, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor. CD3 indicates infiltration level of T lymphocytes (low 0, 1, 2 vs high 3) in primary tumor. FOXP3 indicates infiltration level of regulatory T lymphocytes (low 0 vs high 1, 2, 3). Spearman correlation, two-tailed P value. Bold indicates P value < 0.05