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. 2021 Feb 3;11:624758. doi: 10.3389/fimmu.2020.624758

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Copyright © 2021 Gibson, Kain, Luqmani, Ross, Cabral and Brown

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of LAMP-2-ANCA titer with renal metrics. Concentration of LAMP-2-ANCA (y-axis: ng/ml) in pediatric vasculitis patients: (A) with the absence (n = 15) and presence (n = 36) of proteinuria (x-axis) at the time of diagnosis. (B) plotted against change in GFR from the time of diagnosis to 12-month follow-up (x-axis, ml/min/1.73m²) (n = 25, p = 0.0314). (C) with no renal involvement (renal PVAS < 4; n = 5), and either renal improvement (increase in GFR at 12-month > 10 ml/min/1.73m², n = 8) or worsening (decrease in GFR at 12-month > 10 ml/min/1.73m², n = 12) from diagnosis to 12-month follow-up. (D) plotted against serum creatinine concentration (x-axis; µmol/L) (n = 26, p = 0.2149). Bars show median.