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. 2020 Dec 5;112(2):906–917. doi: 10.1111/cas.14734

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© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Comprehensive proteome analysis was carried out to clarify the role of junctional adhesion molecule‐A (JAM‐A) overexpression. A, Volcano plot of identified unique proteins. B, Venn diagram. A total of 2849 unique proteins were identified, 201 proteins being significantly down‐regulated (ratio < 0.67 and P < .05) and 326 proteins being significantly upregulated (ratio > 1.5 and P < .05) by JAM‐A KO. C, GO analysis of significantly downregulated proteins in JAM‐A KO cells. D, Three candidate molecules were selected from downregulated proteins that might promote malignant potentials in association with JAM‐A in uterine cervical adenocarcinoma