FIGURE 1.

microRNAs’ variation, circulation, and feasible effects in breast cancer (BC) microenvironment as well as variation of the miR‐182‐182‐96 cluster in peripheral blood mononuclear cells (PBMCs) of BC patients. A, A profile of microRNAs, which have a significant alteration in BC patients’ tumor and serum levels (derived from Gene Expression Omnibus [GEO] database). B, microRNAs that predicted targets in the nuclear factor of activated T cells (NFAT) pathway and might be involved in regulatory T cell (Treg) development are shown as Venn diagram (derived from targetscan database). C, Variations of miR‐182‐5p and ‐3p in serum of BC patients (derived from serum data). D, Variations of miR‐182‐5p, ‐3p, miR‐183, and miR‐96 in PBMCs of patients with BC (derived from PBMC data)