Figure 3.

A, Confocal microscopy of the circulating tumor cells (CTCs) and white blood cells (WBCs) isolated from blood samples obtained from patients with localized prostate cancer, metastatic hormone‐sensitive prostate cancer (mHSPC), and metastatic castration‐resistant prostate cancer (mCRPC). Positivity for pan‐cytokeratin (green) was used to identify CTCs, and positivity for CD45 (red) was used to identify WBCs. B, The numbers of isolated CTCs and WBCs per milliliter of blood and the serum PSA levels. C, The WBC depletion rate and (D) the purity of CTCs at each stage of prostate cancer