FIGURE 5.

In vivo NIR‐PIT in mice: changes in tumor volume and body weight. A, Tumor growth curve in the 6 groups. The tumor volumes of group 1 [NIR(+) Pan‐IR700(+) Device(+)] and group 6 mice [NIR(+) Pan‐IR700(+) external irradiation(+)] were significantly suppressed compared with that in group 8 [NIR(−) IR700(−) Device(−)]. The other 4 groups did not show any therapeutic effects. Data are presented as the means ± SEM (n = 4, *P < .01 vs untreated control, Dunnett t test). B, There were no differences in body weight change between any groups during the experiment (n = 3, no significant difference vs untreated control, Dunnett's test)