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Schematic representation of epidermal growth factor (EGF)‐mediated high‐mobility group protein A2 (HMGA2) transcription in hepatocellular carcinoma (HCC) cells. EGF can induce p300 phosphorylation at the Ser1834 site through activation of the PI3K/AKT signaling pathway in HCC; p300 subsequently catalyzes histone H3 acetylation at K9 residues, leading to HMGA2 transcription in HCC. EGFR, epidermal growth factor receptor
