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. Author manuscript; available in PMC: 2021 Feb 19.
Published in final edited form as: ACS Chem Neurosci. 2020 Jul 9;11(15):2316–2326. doi: 10.1021/acschemneuro.0c00276

Table 1.

Association/dissociation rates and affinities of GxTX and Lys27Pra(JP) GxTX for Kv2.1 channels.

GxTX Lys27Pra(JP) GxTX
−100 mV 0 mV −100 mV 0 mV
kon (s−1 nM−1) 3.30 ± 1.10 × 10−4 2.5 ± 1.2 × 10−5 2.16 ± 0.14 × 10−4 1.64 ± 0.90 × 10−5
koff (s−1) 0.84 ± 0.18 × 10−3 38 ± 9 × 10−3 1.80 ± 0.65 × 10−4 8.13 ± 1.39 × 10−3
Kd (nM) 2.55 ± 1.01 1520 ± 810 0.83 ± 0.30 496 ± 285