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. 2021 Feb 17;218(4):e20200472. doi: 10.1084/jem.20200472

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© 2021 Suwankitwat et al.

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Figure 1. — Constitutive disruption of Hem1 results in increased myelopoiesis, neutrophilia, eosinophilia, and lymphopenia. Bar graphs of data from 6–12-wk-old Hem1⁻^/− and WT mice. (A) Complete blood and differential counts. Poly, neutrophils. (B–D) The number of WBCs in BM (B), spleen (C), and blood (D) as determined by flow cytometry. (E and F) Gating strategy and bar graphs depicting the number of PreNeu, immature (Immat.), and mature neutrophils in BM, spleen, and blood (E) and the number of monocytes (Monos) and macrophages (Macs) in BM, spleen, peritoneum (SPMs, CD19⁻CD11c⁻CD11b⁺F4/80^int; LPMs, CD19⁻CD11c⁻CD11b⁺F4/80^hi), and airway (singlet gated, CD45.2⁺ CD11c⁺SiglecF⁺CD11b^intCD64⁺; Misharin et al., 2013; F). Data shown are mean ± SEM from n = 5–7 mice/genotype, six or more independent exps. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; Student’s two-tailed t tests. Lymph, lymphocytes; Mono, monocytes; Eos, eosinophils; PMNs, polymorphonuclear cells; SSC, side scatter.