Table 3. Multivariate cox regression analysis of overall survival in the TCGA cohort and validation cohort.

Factor	TCGA cohort		GSE50081 cohort
	HR (95% CI)	P value	HR (95% CI)	P value
Age (≤65 vs >65)	1.02 [1.00–1.03]	0.061	1.29 [0.69–2.39]	0.428
pT stage (T4 vs T3 vs T2 vs T1)	1.34 [1.11–1.63]	0.003**	2.06 [1.05–4.01]	0.035*
pN stage (N3 vs N2 vs N1 vs N0)	1.48 [1.23–1.78]	<0.001***	1.86 [1.04–3.32]	0.037*
pM stage (M1 vs M0)	1.79 [1.00–3.22]	0.050*	NA	NA
RAD54L expression (high vs low)	1.85 [1.13–3.04]	0.014*	2.39 [1.24–4.61]	0.009**

Notes:

^*P < 0.05.

^**P < 0.01.

^***P < 0.001.

HR, Hazard Ratio; CI, Confidence Interval.