Table 1.
Baseline demographics and clinical characteristics
| ≥2 to <6 years of age | ≥6 months to <2 years of age | |||
|---|---|---|---|---|
|
Dupilumab 3 mg/kg (n = 10) |
Dupilumab 6 mg/kg (n = 10) |
Dupilumab 3 mg/kg (n = 10) |
Dupilumab 6 mg/kg (n = 10) |
|
| "/>Age, mean (SD), months | 45.8 (16.13) | 53.2 (11.23) | 15.4 (6.96) | 15.9 (5.51) |
| Age category, n (%), months | ||||
| ≥48 to <72 | 4 (40.0) | 6 (60.0) | N/A | N/A |
| ≥24 to <48 | 6 (60.0) | 4 (40.0) | N/A | N/A |
| ≥12 to <24 | N/A | N/A | 7 (70.0) | 3 (30.0) |
| ≥6 to <12 | N/A | N/A | 3 (30.0) | 7 (70.0) |
| Male, n (%) | 6 (60.0) | 7 (70.0) | 9 (90.0) | 8 (80.0) |
| Race, n (%) | ||||
| White | 7 (70.0) | 8 (80.0) | 6 (60.0) | 7 (70.0) |
| Black or African American | 3 (30.0) | 1 (10.0) | 1 (10.0) | 2 (20.0) |
| Asian | 0 | 1 (10.0) | 2 (20.0) | 1 (10.0) |
| Weight, mean (SD), kg | 16.57 (3.83) | 17.61 (3.59) | 9.66 (1.67) | 9.89 (1.96) |
| BMI, mean (SD), kg/m2 | 16.15 (1.93) | 16.29 (1.72) | 17.11 (1.81) | 17.53 (2.59) |
| Duration of AD, mean (SD), months | 40.9 (14.32) | 50.6 (10.73) | 13.7 (6.55) | 13.4 (5.44) |
| EASI, mean (SD), scale 0–72 | 35.2 (9.21) | 40.2 (11.81) | 34.4 (14.25) | 36.1 (12.94) |
| Caregiver‐reported Peak Pruritus NRS, mean (SD), scale 0–10 | 8.4 (1.24) | 8.1 (1.45) | 7.6 (2.55) | 8.5 (0.71) |
| BSA involvement, mean (SD), % | 58.1 (11.09) | 67.5 (16.05) | 55.3 (25.66) | 57.9 (21.37) |
| SCORAD score, mean (SD), range 0–103 | 73.5 (10.20) | 75.1 (8.08) | 69.8 (13.10) | 75.9 (11.74) |
| Prior systemic medication use for AD, n (%) | 5 (50.0) | 3 (30.0) | 3 (30.0) | 5 (50.0) |
| Oral corticosteroids | 4 (40.0) | 1 (10.0) | 2 (20.0) | 5 (50.0) |
| Non‐steroidal immunosuppressants | 1 (10.0) | 3 (30.0) | 1 (10.0) | 0 |
| Cyclosporine | 1 (10.0) | 1 (10.0) | 0 | 0 |
| Methotrexate | 0 | 2 (20.0) | 1 (10.0) | 0 |
| Proportions of patients with ≥1 current history of atopic/allergic diseases other than AD, † n (%) | 10 (100.0) | 10 (100.0) | 6 (60.0) | 8 (80.0) |
| Food allergy | 10 (100.0) | 8 (80.0) | 5 (50.0) | 7 (70.0) |
| Allergic rhinitis | 7 (70.0) | 6 (60.0) | 3 (30.0) | 3 (30.0) |
| Other allergies | 6 (60.0) | 4 (40.0) | 1 (10.0) | 5 (50.0) |
| Asthma | 3 (30.0) | 3 (30.0) | 0 | 0 |
| Hives | 3 (30.0) | 2 (20.0) | 1 (10.0) | 1 (10.0) |
| Allergic conjunctivitis (keratoconjunctivitis) | 0 | 2 (20.0) | 0 | 0 |
AD, atopic dermatitis; BMI, body mass index; BSA, body surface area; EASI, Eczema Area and Severity Index; N/A, not applicable; NRS, numerical rating scale; SCORAD, SCORing Atopic Dermatitis; SD, standard deviation.
†
Comorbidities were documented based on history provided by the caregiver.