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Complement pathway: dPGS interferes with the three pathways of complement activation and reduces formation of the membrane attack complex (MAC), which is a pore that is inserted into the cytoplasmic membrane and thereby leads to cell death. Reduced activity of the C3 and C5 convertase results in IC50 values of 60 nm (lectin pathway), 300 nm (classical pathway), and 900 nm (alternative pathway). [200]
