Table 2.
Prediction of Basic ADL Decline from Baseline to 1‐Year Follow Up After TAVI in Older Patients a
| Risk Factor | OR (95% CI) | P‐value | LR χ 2 | NR | C‐statistic |
|---|---|---|---|---|---|
| Comprehensive geriatric assessment parameters | |||||
| Cognitive impairment (MMSE <27 vs ≥27) | 2.91 (1.51–5.58) | .001 | 18.51 | 0.106 | 0.68 |
| Mobility impairment (TUG ≥20 vs <20s) | 2.02 (1.05–3.90) | .04 | 12.60 | 0.073 | 0.66 |
| Malnutrition risk (MNA <12 vs 12 points) | 1.81 (0.96–3.42) | .07 | 11.70 | 0.068 | 0.65 |
| Limitation in basic ADL (≥1 vs 0 limited activity) | 1.31 (0.62–2.74) | .48 | 8.82 | 0.052 | 0.64 |
| Limitation in instrumental ADL (≥1 vs 0 limited activity) | 2.89 (1.33–6.25) | .01 | 16.52 | 0.095 | 0.65 |
| Preclinical mobility disability (disability vs no disability) | 1.62 (0.83–3.19) | .16 | 10.38 | 0.060 | 0.64 |
| Single risk scores | |||||
| Frailty index (per IQR increase, 3 points) | 3.26 (1.72–6.16) | <.001 | 22.27 | 0.127 | 0.71 |
| Logistic EuroSCORE (per IQR increase, 15.7 points) | 0.98 (0.64–1.50) | .94 | 8.34 | 0.049 | 0.61 |
| STS score (per IQR increase, 3.8 points) | 1.16 (0.86–1.57) | .33 | 9.24 | 0.054 | 0.63 |
| Combination of Frailty index with EuroSCORE | |||||
| Combined model (frailty index (A) and EuroSCORE (B)) | NA | <.001 b | 22.27 | 0.127 | 0.71 |
| Frailty index (per IQR increase, 3 points) | 3.26 (1.72–6.16) | <.001 | 0.00 c | ||
| Logistic EuroSCORE (per IQR increase, 15.7 points) | 0.99 (0.64–1.54) | .97 | 13.93 c | ||
| Combination of Frailty index with STS Score | |||||
| Combined model (frailty index (A) and STS score (B)) | NA | <.001 b | 22.58 | 0.129 | 0.72 |
| Frailty index (per IQR increase, 3 points) | 3.21 (1.69–6.11) | <.001 | 0.31 c | ||
| STS score (per IQR increase, 3.8 points) | 1.09 (0.80–1.49) | .57 | 13.34 c | ||
Abbreviations: ADL, activities of daily living; CI, confidence interval; IQR, interquartile range; LR, likelihood ratio chi‐squared test statistic; MMSE, Mini Mental State Exam; MNA, Mini Nutritional Assessment; NA, not applicable; NR, Nagelkerke's R 2; OR, odds ratio; STS, Society of Thoracic Surgeons; TAVI, transcatheter aortic valve implantation; TUG, timed get up and go test.
All models were adjusted for age and gender and were based on the analysis of the sample of patients surviving the 1‐year follow up (N = 278).
P‐value from Wald test of the joint null hypotheses: (A) = (B) = 0 (log odds scale).
Difference of LR of nested model (A + B) minus single risk score model (A) or (B), that is, the value of the nested LR explained by the listed single risk score (A) or (B).