Table 1.

Table to highlight the approaches taken to overcome each challenge faced throughout the pandemic and pipeline creation

Challenge	Approach
As a consequence of social distancing staffing levels had to be reduced.	Staff predominantly worked from home unless required to attend the Crick to aid in assay development.
	Other members of the team were furloughed under the government Coronavirus Job Retention Scheme.
	Employees received mandatory weekly COVID‐19 swab tests to confirm suitability to work.
	A designated place was created in the lab where scientists could safely drop off and collect samples to reduce face‐to‐face contact. Users communicated with scientists via online video calling. Use of some instruments in close proximity was restricted, there was reduced occupancy in laboratories and extended cleaning regimes were put in place.
	Training was suspended to prevent any potential spread of infection, and remote support was provided as required.
The strict and constantly changing timelines for the development of both the assays and pipeline.	The Crick worked closely with a UKAS accredited medical laboratory to quickly meet the governance requirements allowing swift assay development.
Introducing the different approach required to work in diagnostics versus research.	The team was able to draw on diagnostic expertise from existing staff members within the Crick with a diagnostic background.
	We consulted with qualified biomedical scientists within the Crick to highlight where processes need adapting to conform to diagnostic standards.
Restrictions imposed by space available to accommodate equipment and staff.	A complete overhaul of both the layout and laboratory equipment was undertaken in less than a week to meet the requirements of a CL2 diagnostic facility.
Balancing the COVID‐19 pipeline with usual workload responsibilities.	Users previously trained in cell sorting were required to perform their own sorts and analysis and were encouraged to help their nontrained colleagues to use the facility with oversight from the STP staff.
	During lockdown non‐essential flow cytometry work was suspended and external users were banned.
Incorporating COVID‐19 compliant practices into training regimes for new users.	Use of PPE including masks and face shields.
	Development of a series of online videos to provide an alternative to face to face contact.