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Reagents and conditions: i) diphenyl hydrogen phosphonate (DPP), pyridine, 0 °C–38 °C, 3.5 h; ii) a. NCS, CH3CN, RT, 2 h, b) (H2PO4)Bu4N, CH3CN, RT, 1 h; iii) d4T 1, POCl3, pyridine, H2O, CH3CN, 0 °C‐rt, 5 h; iv) a. TFAA, Et3N, CH3CN, 0 °C, 10 min, b. 1‐methylimidazol, Et3N, CH3CN, 0 °C‐rt, 10 min, c. d4TMP 1 m, RT, 3–5 h, RP‐chromatography, Dowex 50WX8 (NH4 + form) ion exchange, RP‐chromatography.
