Table 1.

Hydrolysis of TriPPPro‐compounds 3 in various media.

Prodrug	R1	R2	PB pH=7.3 t 1/2 [h]	CEM/0 cell extracts t 1/2 [h]
3 ae	C2H5	n‐C14H29	59	0.8
3 be	n‐C4H9	n‐C14H29	45	2.5
3 de	n‐C6H13	n‐C14H29	61	2.3
3 ce	iso‐C4H9	n‐C14H29	64	3.8
3 bf	n‐C4H9	n‐C15H31	49	3.1
3 bg	n‐C4H9	n‐C17H35	50	3.3
3 bh	n‐C4H9	MEEES	22	0.8
3 eh	n‐C14H29	MEEES	65	1.1
3 ei	n‐C14H29	MEEEG	86	2.4
D4T	/	/	>40	n.a.[a]
D4TTP31	/	/	>40	0.6