Table 2.
Predicted human PK parameter estimates based on allometric scaling
| Parameter (unit) | Definition | Estimate |
|---|---|---|
| Remdesivir | ||
| VRem (L/kg) | Volume of distribution, plasma | 2.05 |
| kmet (h‐1)a | First‐order metabolic rate constant | 0.268 |
| Nuc | ||
| VNuc,Plasma (L/kg) | Volume of distribution, plasma | 5.35 |
| VNuc,Tissue (L/kg) | Volume of distribution, tissue | 11.7 |
| QNuc (L/hr/kg) | Intercompartmental clearance | 0.158 |
| kLung (h‐1)b | First‐order metabolic rate constant | 0.030 |
| TNuc | ||
| VNTP,Lung (L/kg) | Volume of distribution, lung | 1.69 |
| CLNTP,Lung (L/hr/kg) | Clearance from lung | 0.311 |
Abbreviations: Nuc, GS‐441524; PK, pharmacokinetic; TNuc, total phosphorylated nucleoside.
a
kmet affects remdesivir and Nuc.
b
kLung affects Nuc and TNuc.