Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 19;10(2):137–147. doi: 10.1002/psp4.12582

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, LLC on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Structure of the coproporphyrin I minimal PBPK model. CL_active,u, hepatic uptake clearance (unbound); CL_B, biliary clearance; CL_passive,u, hepatic passive clearance (unbound); CL_R, renal clearance; f_ub, fraction unbound in the blood; f_u,LT, fraction unbound in liver tissue; k_syn, endogenous synthesis rate; Q_H, hepatic blood flow; V_C, volume of central compartment; V_LV, volume of liver vascular; V_LT, volume of liver tissue. An eye symbol represents observed compartments.