Figure 3.

Goodness‐of‐fit (GOF) plots for mechanistic population PBPK modeling of CPI plasma and urine data. Colors represent clinical studies: blue = study 1; red = study 2; and black = study 3. Circles and triangles represent occasions with or without rifampicin administration, respectively. Solid lines are reference lines. The CPI model with k_syn in the blood (central) compartment was used for the simulation. CPI, coproporphyrin I; CWRES, conditional weighted residuals; DV, observed data; IPRED, individual prediction; PRED, population prediction.