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Mitochondrial OCR and animal endurance capacity in 12‐month‐old tazkd mice. (A) OCRs of mitochondria isolated from heart and (B) skeletal muscle oxidizing 5 mm succinate in the presence of 4 µm rotenone. Basal rates were measured in the presence of 1 mm ADP. (C) Duration and (D) distance run by 12‐month‐old wild‐type and tazkd mice until exhaustion. Values are mean ± SEM,n ≧ 3. *P < 0.05;**P < 0.01, using Student's t‐test.
