Table 2.

Thermodynamic parameters of compounds 2, 8, 33 and 40 measured by ITC.

Peptide [a]	K D [nM]	ΔG [kcal mol−1]	ΔH [kcal mol−1]	−TΔS [kcal mol−1]
2 [a]	5.18±0.54	−11.31±0.06	−11.03±0.13	−0.28±0.19
8 [a]	N.B.	–	–	–
33 [a]	8.56±5.83	−11.08±0.44	−7.10±0.02	−3.98±0.42
40 [b]	15.8×103±1.2×103	−6.55±0.04	−4.10±0.13	−2.45±0.09

[a] Measured by titrating 300 μM peptide into a cell containing 30 μM RbAp48 and 416 μM peptide 40. [b] Measured by titrating 800 μM peptide into a cell containing 40 μM RbAp48. N.B.: no binding under the used conditions.