FIG. 1.

Survival of Ghr mutant C57BL/6 mouse strains after PHx. (A) Signaling capabilities of GHR mutant mice. The cytoplasmic domain of receptor is shown, with remaining signaling pathways for each mutant. Ghr391 ^−/− eliminates STAT5 signaling; Box1 ^−/− removes all JAK/STAT signaling while maintaining SFK signaling; and Ghr ^−/− removes all GH mediated signaling. (B) Survival of mouse strains after PHx (number of mice for each genotype shown), in which the mortality of Ghr ^−/− is partially rescued by adenoviral expression of H2‐Bl. Abbreviations: CIS, cytokine‐inducible SH2 (Src homology 2) protein; SHC, Src Homology and Collagen protein; SHP1, Src homology region 2 domain‐containing phosphatase‐1; SHP2, Src homology region 2 domain‐containing phosphatase‐2.