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. 2020 Oct 29;45(2):368–381. doi: 10.1002/cbin.11493

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© 2020 The Authors. Cell Biology International published by John Wiley & Sons Ltd on behalf of International Federation of Cell Biology

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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graphic file with name CBIN-45-368-g004.jpg — Downregulated MARCH1 inhibited CRC cell migration, invasion, and EMT through suppressing PI3K/AKT pathway. (a) The migration ability of the DLD‐1 and sw480 cells transfected with MARCH1 siRNAs and siNC at 24 and 48 h after the scratch using ×40 image lens (scale bar: 200 µm). (b) The invasion ability of the DLD‐1 and sw480 cells transfected with MARCH1 siRNAs and siNC at 48 h using transwell assay (scale bar: 200 µm). (c) Protein expression of EMT, PI3K/AKT pathway molecules in CRC cell lines transfected with MARCH1 siRNAs and siNC at 48 h. Results were presented as mean ± SD of three independent experiments. ***p < .001. CRC, colorectal cancer; EMT, epithelial–mesenchymal transition; MARCH1, membrane‐associated RING‐CH‐1; SD, standard deviation; siRNA, small interfering RNA

graphic file with name CBIN-45-368-g005.jpg — Downregulated MARCH1 inhibited CRC cell migration, invasion, and EMT through suppressing PI3K/AKT pathway. (a) The migration ability of the DLD‐1 and sw480 cells transfected with MARCH1 siRNAs and siNC at 24 and 48 h after the scratch using ×40 image lens (scale bar: 200 µm). (b) The invasion ability of the DLD‐1 and sw480 cells transfected with MARCH1 siRNAs and siNC at 48 h using transwell assay (scale bar: 200 µm). (c) Protein expression of EMT, PI3K/AKT pathway molecules in CRC cell lines transfected with MARCH1 siRNAs and siNC at 48 h. Results were presented as mean ± SD of three independent experiments. ***p < .001. CRC, colorectal cancer; EMT, epithelial–mesenchymal transition; MARCH1, membrane‐associated RING‐CH‐1; SD, standard deviation; siRNA, small interfering RNA