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. 2021 Feb 16;30:0963689721992066. doi: 10.1177/0963689721992066

Figure 4.

Figure 4.

Allogeneic iPSCs form no tumors or tissues in the testicles of MHC-matched macaques. (A) Schema of the transplantation. CMF1/1 -1 and CMT1/1-6 cells were injected into the right testis (★) and left testis (⋆) of macaque #303, respectively. CMF1/1-2 and CMT1/1-4 cells were injected into the right testis (☆) and left testis (※) of macaque #307, respectively. All iPSC clones were injected without Matrigel, and the monkeys were observed for 12 weeks after transplantation. (B) Ultrasonographic images of the testicles after iPSC transplantation. Circles indicate low-echogenic areas where iPSCs were injected. The greater diameters of the low-echogenic areas (mm) are indicated in images taken 1 week after transplantation. (C) Gross appearance of the resected testicles and microscopic findings of HE-stained sections of each testicle excised 3 months after transplantation. The magnification of HE-stained sections is ×40. HE: hematoxylin and eosin; iPSC: induced pluripotent stem cell; MHC: major histocompatibility complex.