Table 6.

Hematopathology Entrustable Professional Activity 5: Select a Flow Immunophenotyping Panel and Compose an Interpretive Report.

Skills

Design/select appropriate flow cytometric initial and follow-up immunophenotyping panels based on clinical and/or morphologic information

Gate and analyze raw flow immunophenotyping data

Recognize common technical and gating errors in flow cytometry and know how to avoid them

Accurately describe and interpret a flow cytometric immunophenotype

Incorporate flow cytometry data into clinical and morphologic context

Knowledge areas

Flow cytometry techniques, including specimen processing and analysis, as well as pitfalls in analysis and interpretation

Example scenarios

Design/pick an appropriate flow cytometry panel for a low cellularity cerebrospinal fluid specimen in a patient with known lymphoma history

Recognize typical and atypical immunophenotypic patterns for chronic lymphocytic leukemia

Distinguish between hematogones (normal B-lineage precursors) and leukemic B-lymphoblasts

Assign lineage to an acute leukemia. Recognize reactive and neoplastic T antigen abnormalities

ACGME Hematopathology Milestones version 2.0

Patient Care 1 and 2: Interdisciplinary consultation, reporting

Medical Knowledge 3 and 6: Interpretation of flow cytometry, clinical reasoning in hematopathology and hematology

Practice-Based Learning and Improvement 1 and 2: Evidence-based practice and scholarship, reflective practice and commitment to personal growth

Professionalism 1, 2, and 3: Professional behavior and ethical principles, accountability and conscientiousness, self-awareness and help-seeking

Interpersonal and Communication Skills 2 and 3: Interprofessional and team communication, communication within health care systems

Abbreviation: ACGME, Accreditation Council for Graduate Medical Education.