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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2021 Jan 12;30(3):105595. doi: 10.1016/j.jstrokecerebrovasdis.2020.105595

Figure 2. Hemorrhagic transformation is reduced by glibenclamide in cohort 1.

Figure 2.

(A) Examples of the different HT categories are provided. HI1: small petechiae along the periphery of the infarct; HI2: confluent petechiae within infarct area; PH1: blood visible within <30% of infarct area. There was less severe HT in the animals treated with glibenclamide (white bars) compared to control (gray bars; p<0.001). (B) Quantitative assessment of HT density on brain slice photographs also showed that glibenclamide reduced the mean density ratio (*** p<0.001). (C) The mean density ratio on photographs correlated with brain hemorrhage volume measured using spectrophotometry (r=0.76, p<0.001). (D) Accordingly, glibenclamide reduced brain hemorrhage volume relative to control (**, p=0.01).