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Export of intracellular S1P (iS1P) by cell-specific S1P transporters regulates the S1P gradient. This turnover of intracellularly generated S1P leads to low iS1P and high eS1P concentrations and allows for the formation of a spatial gradient that is crucial for S1P to exercise its biologic activities. ABCC1, ATP-binding cassette transporter C1; MFSD2B, major facilitator superfamily domain containing 2B; PM, plasma membrane; SPNS2, sphingolipid transporter 2.
