Figure 4.

Higher plasma biomarker concetrations (per increment in log2 biomarker values) of TNFR-1, TNFR-2, KIM-1, and YKL-40 were significantly associated with the annual rate of decline in eGFR (ml/min per 1.73 m² per year) after adjustment for age, sex, race/ethnicity, education, clinical center, systolic BP, diastolic BP, BMI, hsCRP, hemoglobin A1c, antihypertensive medication use, smoking status, baseline eGFR (ml/min per 1.73 m²), and UPCR. All β-coefficients are adjusted for age, sex, race/ethnicity, education, clinical center, systolic BP, diastolic BP, BMI, hsCRP, hemoglobin A1c, antihypertensive medication use, smoking status, baseline eGFR (ml/min per 1.73 m²), and UPCR.