Table 2. Differently expressed genes identified by RT2-profilers arrays in the liver of 35 versus 14 days old Normal Birth Weight (NBW) piglets.
| Arrays/ Genesa | Description | Foldb | p-valuesc | FDRd |
|---|---|---|---|---|
| Oxidative stress | ||||
| ALB | Albumin | -3.78 | <0.01 | 0.037 |
| ALOX12 | Arachidonate 12-lipoxygenase | -5.02 | <0.01 | 0.083 |
| APOE | Apolipoprotein E | -2.26 | <0.01 | 0.99 |
| CCL5 | Chemokine (C-C motif) ligand 5 | -2.24 | <0.01 | 0.083 |
| FOXM1 | Forkhead box M1 | -3.62 | 0.049 | 0.188 |
| GPX3 | Glutathione peroxidase 3 (plasma) | -4.57 | 0.015 | 0.126 |
| MT-III | Metallothionein-III | -5.96 | <0.01 | 0.068 |
| PTGR1 | Prostaglandin reductase 1 | 3.61 | 0.020 | 0.158 |
| TTNLOC100620261 | Titin | -37.57 | 0.038 | 0.183 |
| TXN | Thioredoxin | 2.80 | 0.012 | 0.107 |
| TXNRD2 | Thioredoxin reductase 2 | -2.06 | <0.01 | 0.083 |
| Mito. energy | ||||
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | -3.49 | 0.031 | 0.156 |
| ATP6V1G3 | V-type proton ATPase subunit G 3-like | -2.92 | <0.01 | 0.087 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -2.93 | 0.035 | 0.156 |
| HSP70.2 | Heat shock protein 70.2 | -6.42 | 0.015 | 0.141 |
| LOC100154992 | Mitochondrial inner membrane protein OXA1L-like | -2.84 | 0.035 | 0.156 |
| NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like | -2.18 | 0.037 | 0.156 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | -88.59 | 0.012 | 0.135 |
| NDUFS2 | NADH dehydrogenase (ubiquinone) (NADH-coenzyme Q reductase) | -16.72 | 0.036 | 0.156 |
| NDUFS3 | NADH dehydrogenase (ubiquinone) (NADH-coenzyme Q reductase) | -2.28 | 0.019 | 0.149 |
| NDUFS7 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial-like | -2.02 | 0.038 | 0.156 |
| SDHA | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | -2.68 | 0.036 | 0.156 |
| SDHB | Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -2.94 | 0.030 | 0.156 |
aRT2-profilers used were oxidative stress and mitochondrial energy metabolism (mito. energy) and each array included 84 genes.
bFold change (2-ΔΔCt) is the normalized gene expression (2-ΔCt)) at d 23 divided the normalized gene expression (2-ΔCt) at d 14. Fold-change values greater than one indicates a positive- or an up-regulation and values less than one indicate a negative or down-regulation.
cThe p values are calculated based on a Student’s t-test of the replicate (2-ΔCt) values for each gene from NBW piglets of both ages.
dThe FDR is the False Discovery Rate adjusted p-values.