Table 3. Relative abundance of genus level taxa (percent of total sequences) in the fecal microbiota of 4 cats prior to and following experimentally induced T. foetus infection.
| Median % abundance [Range min to max] |
Kruskal-Wallis ANOVA |
|||||
|---|---|---|---|---|---|---|
| Phylum | Family | Genus | Pre-infection | 2 weeks post-infection | 9 weeks post-infection | |
| p-value | ||||||
| Actinobacteria | 1.45 [0.25–4.72] | 0.54 [0.18–1.21] | 0.39 [0.01–2.84] | 0.706 | ||
| Bifidobacteriaceae | Bifidobacterium | 0.01 [0.0–0.03] | 0.00 [0.0–0.0] | 0.00 [0.0–0.01] | 0.136 | |
| Coriobacteriaceae | Adlercreutzia | 0.05 [0.01–0.1] | 0.04 [0.01–0.11] | 0.06 [0.0–0.12] | 1.000 | |
| Collinsella | 1.33 [0.23–4.65] | 0.48 [0.13–1.03] | 0.33 [0.01–2.55] | 0.706 | ||
| Bacteroidetes | 60.16 [51.79–61.82] | 59.53 [53.31–64.53] | 56.81 [50.80–66.33] | 0.815 | ||
| Bacteroidaceae | Bacteroides | 10.45 [9.64–16.54] | 16.21 [15.17–17.05] | 16.23 [14.61–23.30] | 0.136 | |
| Porphyromonadaceae | Parabacteroides | 1.31 [0.52–2.23] | 2.14 [2.02–2.45] | 1.60 [1.38–2.17] | 0.197 | |
| Prevotellaceae | Prevotella | 29.69 [25.78–33.00] | 21.08 [18.70–27.07] | 25.26 [9.18–27.40] | 0.044* | |
| Rikenellaceae | Uncl. Rikenellaceae | 0.00 [0.0–0.03] | 0.08 [0.0–0.18] | 0.06 [0.0–0.14] | 0.173 | |
| Alistipes | 0.18 [0.01-.33] | 0.36 [0.08–0.95] | 0.09 [0.05–0.92] | 0.540 | ||
| S24-7 | Uncl. S24-7 | 0.77 [0.61–0.94] | 1.72 [0.88–2.75] | 0.90 [0.40–1.01] | 0.074 | |
| [Odoribacteraceae] | Odoribacter | 0.43 [0.16–1.04] | 0.77 [0.62–0.95] | 0.59 [0.22–1.08] | 0.592 | |
| [Paraprevotellacea] | Paraprevotella | 0.07 [0.04–0.13] | 0.10 [0.04–0.17] | 0.11 [0.08–0.23] | 0.397 | |
| [Prevotella] | 13.01 [9.36–21.52] | 15.10 [13.51–19.13] | 14.77 [9.37–19.92] | 0.770 | ||
| Firmicutes | 28.96 [27.83–36.96] | 22.60 [20.25–26.23] | 22.01 [18.24–30.92] | 0.086 | ||
| Lactobacillaceae | Lactobacillus | 0.00 [0.0–0.01] | 0.00 [0.0–0.01] | 0.00 [0.0–0.03] | 0.941 | |
| Leuconostocaceae | Leuconostoc | 0.00 [0.0–0.0] | 0.00 [0.0–0.01] | 0.00 [0.0–0.01] | 0.630 | |
| Streptococcaceae | Lactococcus | 0.01 [0.0–0.02] | 0.01 [0.0–0.02] | 0.03 [0.01–0.03] | 0.040* | |
| Streptococcus | 0.00 [0.0–0.06] | 0.00 [0.0–0.21] | 0.01 [0.0–0.03] | 0.968 | ||
| Uncl. Clostridiales | Uncl. Clostridiales | 0.73 [0.60–1.35] | 1.57 [0.57–1.98] | 1.27 [0.71–2.06] | 0.436 | |
| Clostridiaceae | Candidatus Arthromitus | 0.16 [0.0–0.46] | 0.13 [0.01–0.65] | 0.03 [0.01–0.13] | 0.480 | |
| Clostridium | 0.36 [0.15–0.89] | 0.26 [0.09–0.46] | 0.16 [0.07–0.54] | 0.452 | ||
| Lachnospiraceae | Uncl. Lachnospiraceae | 1.94 [0.75–2.58] | 2.77 [1.79–3.21] | 2.42 [2.34–4.76] | 0.252 | |
| Blautia | 0.39 [0.20–0.72] | 0.34 [0.19–0.43] | 0.35 [0.12–1.00] | 0.913 | ||
| Clostridium | 0.07 [0.0–0.15] | 0.02 [0.02–0.03] | 0.01 [0.0–0.04] | 0.397 | ||
| Coprococcus | 0.03 [0.0–0.03] | 0.04 [0.01–0.04] | 0.03 [0.01–0.19] | 0.540 | ||
| Dorea | 0.10 [0.04–0.32] | 0.05 [0.01–0.12] | 0.02 [0.01–0.08] | 0.234 | ||
| Lachnospira | 0.00 [0.0–0.16] | 0.43 [0.0–0.69] | 0.60 [0.07–1.11] | 0.074 | ||
| Roseburia | 0.54 [0.17–0.83] | 0.36 [0.01–0.47] | 0.77 [0.13–4.21] | 0.592 | ||
| [Ruminococcus] | 0.12 [0.09–0.27] | 0.07 [0.06–0.14] | 0.09 [0.07–0.45] | 0.277 | ||
| Peptococcaceae | Peptococcus | 0.16 [0.02–0.25] | 0.08 [0.03–0.18] | 0.07 [0.03–0.16] | 0.706 | |
| Peptostreptococcaceae | Uncl. Peptostreptococcaceae | 0.69 [0.12–6.23] | 0.59 [0.07–1.55] | 0.08 [0.0–0.52] | 0.252 | |
| Ruminococcaceae | Uncl. Ruminococcaceae | 1.75 [0.65–2.70] | 1.47 [1.14–2.82] | 1.28 [0.69–3.71] | 0.968 | |
| Butyricicoccus | 0.01 [0.01–0.01] | 0.01 [0.0–0.01] | 0.01 [0.01–0.03] | 0.592 | ||
| Faecalibacterium | 2.68 [1.83–5.03] | 3.36 [2.26–4.40] | 2.87 [0.65–3.75] | 0.840 | ||
| Oscillospira | 1.14 [0.40–1.54] | 1.03 [0.71–1.37] | 0.94 [0.61–1.34] | 0.941 | ||
| Ruminococcus | 0.13 [0.02–0.21] | 0.22 [0.19–0.27] | 0.21 [0.16–0.47] | 0.074 | ||
| Veillonellaceae | Acidaminococcus | 0.75 [0.08–2.66] | 0.33 [0.07–0.92] | 0.09 [0.01–0.23] | 0.145 | |
| Dialister | 10.54 [8.42–11.66] | 6.17 [5.06–7.30] | 7.09 [6.72–7.69] | 0.002**† | ||
| Megamonas | 0.83 [0.72–2.14] | 0.18 [0.18–0.20] | 0.10 [0.04–0.46] | 0.005**† | ||
| Megasphaera | 2.36 [1.49–3.65] | 0.77 [0.47–1.92] | 0.56 [0.26–0.68] | 0.016* | ||
| Mitsuokella | 0.05 [0.0–0.82] | 0.00 [0.0–0.15] | 0.00 [0.0–0.01] | 0.706 | ||
| [Mogibacteriaceae] | Uncl. [Mogibacteriaceae] | 0.79 [0.24–1.17] | 0.41 [0.15–0.62] | 0.34 [0.14–0.83] | 0.252 | |
| Erysipelotrichaceae | Uncl. Erysipelotrichaceae | 0.05 [0.0–0.09] | 0.00 [0.0–0.0] | 0.03 [0.0–0.14] | 0.131 | |
| Allobaculum | 0.01 [0.0–0.03] | 0.07 [0.0–0.25] | 0.04 [0.02–0.18] | 0.370 | ||
| Bulleidia | 0.00 [0.0–0.10] | 0.00 [0.0–0.19] | 0.00 [0.0–0.49] | 0.941 | ||
| Catenibacterium | 0.41 [0.13–0.72] | 0.46 [0.18–0.62] | 0.38 [0.12–1.63] | 0.968 | ||
| Holdemania | 0.02 [0.0–0.02] | 0.02 [0.02–0.04] | 0.02 [0.01–0.94] | 0.540 | ||
| [Eubacterium] | 0.20 [0.09–0.31] | 0.21 [0.17–0.30] | 0.18 [0.10–0.50] | 0.913 | ||
| Fusobacteria | 2.59 [1.68–3.34] | 5.07 [2.06–6.78] | 5.22 [4.34–8.00] | 0.074 | ||
| Uncl. Fusobacteriaceae | Uncl. Fusobacteriaceae | 1.80 [1.06–2.65] | 4.08 [1.91–5.40] | 3.85 [3.25–5.72] | 0.026* | |
| Fusobacteriaceae | Uncl. Fusobacteriaceae | 0.66 [0.62–0.94] | 0.99 [0.15–1.37] | 1.50 [0.82–2.27] | 0.063 | |
| Proteobacteria | 6.60 [4.69–6.72] | 12.51 [10.62–13.91] | 11.64 [9.42–16.49] | 0.011* | ||
| Betaproteobacteria (class) | 0.01 [0.01–0.03] | 0.19 [0.10–0.32] | 0.12 [0.04–0.16] | 0.002**† | ||
| Burkholderiales (order) | 0.74 [0.58–0.98] | 2.53 [1.29–2.95] | 2.04 [0.59–2.62] | 0.055 | ||
| Alcaligenaceae | Sutterella | 2.19 [1.61–2.69] | 3.31 [2.53–4.91] | 3.79 [1.72–7.07] | 0.348 | |
| Methylophilaceae | Methylotenera | 0.00 [0.0–0.0] | 0.00 [0.0–0.0] | 0.00 [0.0–0.0] | 1.000 | |
| Desulfovibrionaceae | Uncl. Desulfovibrionaceae | 0.15 [0.13–0.21] | 0.30 [0.19–0.43] | 0.23 [0.12–0.32] | 0.122 | |
| Desulfovibrio | 0.89 [0.22–1.68] | 1.14 [0.65–1.55] | 1.31 [0.73–1.44] | 0.840 | ||
| Campylobacteraceae | Campylobacter | 1.70 [1.13–2.07] | 4.92 [1.45–6.64] | 4.02 [2.37–6.68] | 0.080 | |
| Succinivibrionaceae | Uncl. Succinivibrionaceae | 0.03 [0.01–0.05] | 0.16 [0.14-.18] | 0.30 [0.14–0.57] | 0.007**† | |
| Succinivibrio | 0.37 [0.19–0.80] | 0.24 [0.11–0.28] | 0.16 [0.08–0.36] | 0.234 | ||
| Enterobacteriaceae | Uncl. Enterobacteriaceae | 0.02 [0.0–0.04] | 0.01 [0.0–0.09] | 0.04 [0.02–0.08] | 0.252 | |
| Pseudomonadaceae | Pseudomonas | 0.00 [0.0–0.0] | 0.00 [0.0–0.0] | 0.00 [0.0–0.0] | 1.000 | |
*p<0.05 and
**p<0.01.
†Benjamini-Hochberg corrected p-value <0.15.