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The 3D spatial shape of CPPs predicted by PEP-FOLD3 web server: (A) EASKKPRQKR peptide containing tumor penetrating motif (RXXR); (B) GIEFLKRGDK peptide containing tumor homing motif (RGD); (C) RSGARSKQRR peptide with +5.00 net charge; (D) VVLKKLKKSL peptide with high half-life (~100 hour) in mammalian cells; (E) SSRSRNSSRN peptide with the highest Boman index (~7.5); (F) MCYKRNRATR peptide containing tumor penetrating motif (RXXR).
