Table 1. Predicted CPPs and their uptake efficiency using various web servers.
| Epitope | CellPPD (SVM score) | CPP Probability score by C2Pred* | Uptake efficiency by MLCPP | Uptake efficiency by CPPred-RF |
|---|---|---|---|---|
| S protein | ||||
| NLTTRTQLPP | 0.03 | 0.549136 | Low | High |
| RFQTLLALHR | 0.11 | 0.924753 | Low | High |
| YLQPRTFLLK | 0.05 | 0.745663 | Low | High |
| SVYAWNRKRI | 0.12 | 0.542719 | Low | High |
| YAWNRKRISN | 0.21 | 0.581372 | Low | High |
| AWNRKRISNC | 0.10 | 0.581372 | Low | High |
| WNRKRISNCV | 0.07 | 0.422121 | Low | High |
| RQIAPGQTGK | 0.05 | 0.480859 | Low | High |
| YNYLYRLFRK | 0.10 | 0.434133 | High | High |
| YLYRLFRKSN | 0.17 | 0.323746 | High | High |
| YRLFRKSNLK | 0.18 | 0.651294 | Low | High |
| RLFRKSNLKP | 0.18 | 0.633622 | Low | High |
| RKSNLKPFER | 0.14 | 0.800554 | Low | High |
| KKSTNLVKNK | 0.33 | 0.588285 | Low | High |
| KSTNLVKNKC | 0.06 | 0.527724 | Low | High |
| HADQLTPTWR | 0.00 | 0.545188 | Low | Non-CPP |
| YQTQTNSPRR | 0.11 | 0.149319 | Low | High |
| TQTNSPRRAR | 0.11 | 0.143146 | Low | High |
| TNSPRRARSV | 0.16 | 0.142480 | Low | High |
| NSPRRARSVA | 0.14 | 0.108221 | Low | High |
| PRRARSVASQ | 0.17 | 0.236319 | Low | High |
| KQIYKTPPIK | 0.46 | 0.944703 | Low | High |
| SQILPDPSKP | 0.03 | 0.906582 | Low | High |
| RLITGRLQSL | 0.21 | 0.663600 | Low | High |
| M protein | ||||
| NRNRFLYIIK | 0.02 | 0.220554 | Low | High |
| RNRFLYIIKL | 0.18 | 0.114117 | Low | High |
| YIIKLIFLWL | 0.01 | 0.669640 | Low | High |
| KLIFLWLLWP | 0.31 | 0.709344 | Low | High |
| FIASFRLFAR | 0.10 | 0.421173 | Low | High |
| ASFRLFARTR | 0.20 | 0.594022 | Low | High |
| SFRLFARTRS | 0.06 | 0.553645 | Low | High |
| FRLFARTRSM | 0.21 | 0.385465 | Low | High |
| RLFARTRSMW | 0.28 | 0.383433 | Low | High |
| FARTRSMWSF | 0.04 | 0.463913 | Low | High |
| HGTILTRPLL | 0.03 | 0.430916 | Low | High |
| GAVILRGHLR | 0.13 | 0.223997 | High | High |
| RIAGHHLGRC | 0.02 | 0.243928 | Low | High |
| YSRYRIGNYK | 0.05 | 0.897477 | Low | High |
| N protein | ||||
| PQNQRNAPRI | 0.09 | 0.413323 | Low | High |
| ERSGARSKQR | 0.06 | 0.261718 | Low | High |
| RSGARSKQRR | 0.54 | 0.292041 | Low | High |
| SGARSKQRRP | 0.25 | 0.300551 | Low | High |
| GARSKQRRPQ | 0.40 | 0.250417 | Low | High |
| ARSKQRRPQG | 0.17 | 0.298689 | Low | High |
| RSKQRRPQGL | 0.36 | 0.192042 | Low | High |
| SKQRRPQGLP | 0.06 | 0.164110 | Low | High |
| KQRRPQGLPN | 0.18 | 0.206509 | Low | High |
| RRPQGLPNNT | 0.12 | 0.216779 | Low | High |
| QIGYYRRATR | 0.09 | 0.531651 | Low | High |
| IGYYRRATRR | 0.23 | 0.604819 | Low | High |
| GYYRRATRRI | 0.29 | 0.965070 | Low | High |
| YYRRATRRIR | 0.58 | 0.952696 | Low | High |
| YRRATRRIRG | 0.59 | 0.935039 | Low | High |
| RRATRRIRGG | 0.56 | 0.939794 | Low | High |
| RATRRIRGGD | 0.33 | 0.924855 | Low | High |
| TRRIRGGDGK | 0.10 | 0.369598 | Low | High |
| RIRGGDGKMK | 0.11 | 0.250269 | Low | High |
| GKMKDLSPRW | 0.02 | 0.735642 | Low | High |
| SQASSRSSSR | 0.05 | 0.677066 | Low | High |
| ASSRSSSRSR | 0.17 | 0.304528 | Low | High |
| SSRSSSRSRN | 0.09 | 0.304528 | Low | High |
| SRSSSRSRNS | 0.14 | 0.297448 | Low | High |
| RSSSRSRNSS | 0.12 | 0.432735 | Low | High |
| SSSRSRNSSR | 0.13 | 0.315140 | Low | High |
| SSRSRNSSRN | 0.10 | 0.315140 | Low | High |
| RSRNSSRNST | 0.04 | 0.359073 | Low | High |
| GSSRGTSPAR | 0.06 | 0.716403 | Low | High |
| AALALLLLDR | 0.14 | 0.898706 | Low | High |
| ALALLLLDRL | 0.05 | 0.895190 | Low | High |
| KKSAAEASKK | 0.33 | 0.730535 | Low | High |
| KSAAEASKKP | 0.13 | 0.669679 | Low | High |
| SAAEASKKPR | 0.06 | 0.669679 | Low | High |
| AAEASKKPRQ | 0.10 | 0.963042 | Low | High |
| AEASKKPRQK | 0.15 | 0.96509 | Low | High |
| EASKKPRQKR | 0.34 | 0.988105 | Low | High |
| ASKKPRQKRT | 0.28 | 0.947786 | Low | High |
| SKKPRQKRTA | 0.32 | 0.947786 | Low | High |
| KKPRQKRTAT | 0.47 | 0.947786 | Low | High |
| KPRQKRTATK | 0.42 | 0.941370 | Low | High |
| PRQKRTATKA | 0.23 | 0.936878 | Low | High |
| RQKRTATKAY | 0.13 | 0.936878 | Low | High |
| RQGTDYKHWP | 0.02 | 0.249058 | Low | High |
| FPPTEPKKDK | 0.04 | 0.937092 | Low | Non-CPP |
| PPTEPKKDKK | 0.12 | 0.954110 | Low | High |
| PTEPKKDKKK | 0.20 | 0.965728 | Low | High |
| TEPKKDKKKK | 0.51 | 0.972132 | Low | High |
| EPKKDKKKKA | 0.35 | 0.969009 | Low | High |
| PKKDKKKKAD | 0.28 | 0.736106 | Low | High |
| KKDKKKKADE | 0.26 | 0.275127 | Low | High |
| TQALPQRQKK | 0.11 | 0.378326 | Low | High |
| ALPQRQKKQQ | 0.17 | 0.715403 | Low | High |
| ORF3a | ||||
| SASKIITLKK | 0.07 | 0.666607 | Low | High |
| ASKIITLKKR | 0.19 | 0.975854 | Low | High |
| SKIITLKKRW | 0.31 | 0.977206 | Low | High |
| KIITLKKRWQ | 0.56 | 0.977206 | Low | High |
| IITLKKRWQL | 0.04 | 0.981679 | Low | High |
| KKRWQLALSK | 0.47 | 0.908996 | Low | High |
| KRWQLALSKG | 0.31 | 0.711236 | Low | High |
| VRIIMRLWLC | 0.11 | 0.512905 | Low | High |
| RIIMRLWLCW | 0.25 | 0.512905 | Low | High |
| IIMRLWLCWK | 0.14 | 0.584110 | Low | High |
| IMRLWLCWKC | 0.06 | 0.584110 | High | High |
| MRLWLCWKCR | 0.17 | 0.584110 | High | High |
| RLWLCWKCRS | 0.22 | 0.578205 | High | High |
| LWLCWKCRSK | 0.28 | 0.516957 | High | High |
| WLCWKCRSKN | 0.12 | 0.456487 | High | High |
| LCWKCRSKNP | 0.16 | 0.456487 | High | High |
| CWKCRSKNPL | 0.14 | 0.815386 | High | High |
| KCRSKNPLLY | 0.10 | 0.172543 | Low | High |
| Orf1ab | ||||
| IKRSDARTAP | 0.00 | 0.611515 | Low | High |
| KRSDARTAPH | 0.08 | 0.611515 | Low | High |
| PVAYRKVLLR | 0.05 | 0.395891 | High | High |
| VAYRKVLLRK | 0.07 | 0.461402 | High | High |
| AYRKVLLRKN | 0.13 | 0.873577 | Low | High |
| YRKVLLRKNG | 0.05 | 0.873577 | Low | High |
| RKVLLRKNGN | 0.14 | 0.892119 | Low | High |
| KVLLRKNGNK | 0.01 | 0.921012 | Low | High |
| FEIKLAKKFD | 0.09 | 0.877125 | Low | High |
| KTIQPRVEKK | 0.39 | 0.961264 | Low | High |
| TIQPRVEKKK | 0.13 | 0.954110 | Low | High |
| IQPRVEKKKL | 0.13 | 0.953833 | Low | High |
| SGLKTILRKG | 0.02 | 0.624757 | Low | High |
| LKTILRKGGR | 0.24 | 0.808425 | Low | High |
| KTILRKGGRT | 0.15 | 0.805867 | Low | High |
| GNFKVTKGKA | 0.03 | 0.385736 | Low | High |
| FKVTKGKAKK | 0.35 | 0.445305 | Low | High |
| KVTKGKAKKG | 0.26 | 0.339767 | Low | High |
| KGKAKKGAWN | 0.07 | 0.184903 | Low | High |
| GGAKLKALNL | 0.04 | 0.430832 | Low | High |
| SKGLYRKCVK | 0.09 | 0.145729 | Low | High |
| KGLYRKCVKS | 0.07 | 0.145729 | Low | High |
| GLYRKCVKSR | 0.34 | 0.274849 | Low | High |
| GLLMPLKAPK | 0.09 | 0.427961 | Low | High |
| QRKQDDKKIK | 0.15 | 0.861718 | Low | High |
| RKQDDKKIKA | 0.17 | 0.976533 | Low | High |
| KQDDKKIKAC | 0.07 | 0.318404 | Low | High |
| DITFLKKDAP | 0.03 | 0.682254 | Low | Non-CPP |
| MLAKALRKVP | 0.28 | 0.671110 | High | High |
| LAKALRKVPT | 0.08 | 0.671110 | Low | High |
| EAKTVLKKCK | 0.13 | 0.717688 | Low | High |
| AKTVLKKCKS | 0.13 | 0.717688 | Low | High |
| KTVLKKCKSA | 0.22 | 0.546244 | Low | High |
| KSAFYILPSI | 0.00 | 0.108440 | Low | High |
| KAIVSTIQRK | 0.08 | 0.204524 | Low | High |
| STIQRKYKGI | 0.07 | 0.433511 | Low | High |
| TIQRKYKGIK | 0.13 | 0.433511 | Low | High |
| IQRKYKGIKI | 0.08 | 0.433511 | Low | High |
| GARFYFYTSK | 0.04 | 0.178363 | Low | High |
| ARYMRSLKVP | 0.06 | 0.471501 | Low | High |
| GIEFLKRGDK | 0.08 | 0.224238 | Low | High |
| DNLKTLLSLR | 0.03 | 0.361469 | High | Non-CPP |
| YMSALNHTKK | 0.05 | 0.330689 | Low | High |
| SALNHTKKWK | 0.12 | 0.709364 | Low | High |
| ALNHTKKWKY | 0.10 | 0.888647 | Low | High |
| LNHTKKWKYP | 0.14 | 0.913973 | Low | High |
| NHTKKWKYPQ | 0.10 | 0.678789 | Low | High |
| HTKKWKYPQV | 0.04 | 0.303493 | Low | Non-CPP |
| KKPASRELKV | 0.14 | 0.769021 | Low | High |
| KPASRELKVT | 0.07 | 0.743805 | Low | High |
| YTPSFKKGAK | 0.08 | 0.164140 | Low | High |
| PSFKKGAKLL | 0.00 | 0.210028 | Low | High |
| FKKGAKLLHK | 0.16 | 0.308486 | Low | High |
| KKGAKLLHKP | 0.48 | 0.308486 | Low | High |
| KGAKLLHKPI | 0.32 | 0.261312 | Low | High |
| WCIRCLWSTK | 0.12 | 0.727461 | High | High |
| CIRCLWSTKP | 0.20 | 0.727461 | Low | High |
| ANYAKPFLNK | 0.01 | 0.474322 | Low | High |
| TNIVTRCLNR | 0.01 | 0.309069 | Low | High |
| CTFTRSTNSR | 0.02 | 0.513802 | Low | High |
| TCMMCYKRNR | 0.01 | 0.331608 | High | High |
| MCYKRNRATR | 0.25 | 0.936560 | Low | High |
| CYKRNRATRV | 0.03 | 0.936560 | Low | High |
| YKRNRATRVE | 0.00 | 0.936560 | Low | High |
| KRNRATRVEC | 0.18 | 0.532289 | Low | High |
| RNRATRVECT | 0.06 | 0.325111 | Low | High |
| RDLSLQFKRP | 0.17 | 0.903779 | Low | High |
| SLQFKRPINP | 0.14 | 0.353192 | Low | High |
| HNIALIWNVK | 0.01 | 0.377627 | Low | High |
| LSEQLRKQIR | 0.04 | 0.269638 | Low | High |
| QLRKQIRSAA | 0.03 | 0.615417 | Low | High |
| LRKQIRSAAK | 0.02 | 0.718721 | Low | High |
| RKQIRSAAKK | 0.30 | 0.751730 | Low | High |
| KQIRSAAKKN | 0.38 | 0.729912 | Low | High |
| QIRSAAKKNN | 0.11 | 0.729912 | Low | High |
| AAKKNNLPFK | 0.09 | 0.933084 | Low | High |
| KKNNLPFKLT | 0.04 | 0.938618 | Low | High |
| NNWLKQLIKV | 0.01 | 0.793676 | High | High |
| LAYYFMRFRR | 0.04 | 0.301382 | Low | High |
| AYYFMRFRRA | 0.05 | 0.289065 | Low | High |
| YYFMRFRRAF | 0.08 | 0.182381 | High | High |
| FMRFRRAFGE | 0.05 | 0.167797 | High | High |
| MRFRRAFGEY | 0.05 | 0.167797 | High | High |
| KEMYLKLRSD | 0.02 | 0.354324 | Low | High |
| YNRYLALYNK | 0.03 | 0.241742 | High | High |
| RYLALYNKYK | 0.03 | 0.232393 | High | High |
| FRKMAFPSGK | 0.03 | 0.318037 | Low | High |
| TANPKTPKYK | 0.15 | 0.944703 | Low | High |
| ANPKTPKYKF | 0.03 | 0.944703 | Low | High |
| PKTPKYKFVR | 0.12 | 0.944703 | Low | High |
| KTPKYKFVRI | 0.10 | 0.917400 | Low | High |
| RWFLNRFTTT | 0.02 | 0.601321 | Low | High |
| FQSAVKRTIK | 0.08 | 0.586710 | Low | High |
| SEVVLKKLKK | 0.24 | 0.204172 | Low | High |
| VVLKKLKKSL | 0.09 | 0.270145 | Low | High |
| VLKKLKKSLN | 0.12 | 0.910975 | Low | High |
| KKLKKSLNVA | 0.15 | 0.190690 | Low | High |
| DAAMQRKLEK | 0.00 | 0.372134 | Low | High |
| AAMQRKLEKM | 0.01 | 0.372134 | Low | High |
| MQRKLEKMAD | 0.16 | 0.525121 | Low | High |
| YKQARSEDKR | 0.02 | 0.246035 | Low | High |
| KQARSEDKRA | 0.13 | 0.242658 | Low | High |
| QARSEDKRAK | 0.05 | 0.242658 | Low | High |
| MLFTMLRKLD | 0.05 | 0.894360 | Low | Non-CPP |
| QDLKWARFPK | 0.02 | 0.860963 | Low | High |
| DLKWARFPKS | 0.08 | 0.860963 | Low | Non-CPP |
| LKWARFPKSD | 0.22 | 0.397145 | Low | High |
| KGFCDLKGKY | 0.06 | 0.207285 | Low | High |
| GVSAARLTPC | 0.03 | 0.277471 | Low | High |
| GFAKFLKTNC | 0.01 | 0.119116 | Low | Non-CPP |
| KTNCCRFQEK | 0.08 | 0.481756 | Low | High |
| PHISRQRLTK | 0.28 | 0.636709 | Low | High |
| HISRQRLTKY | 0.24 | 0.636709 | Low | High |
| ISRQRLTKYT | 0.11 | 0.636709 | Low | High |
| SRQRLTKYTM | 0.01 | 0.835148 | Low | High |
| RQRLTKYTMA | 0.11 | 0.878279 | Low | High |
| GERVRQALLK | 0.09 | 0.849631 | Low | High |
| RVRQALLKTV | 0.09 | 0.932330 | High | High |
| KPYIKWDLLK | 0.01 | 0.876722 | Low | High |
| RLKLFDRYFK | 0.05 | 0.261079 | Low | High |
| KLFDRYFKYW | 0.04 | 0.219406 | High | Non-CPP |
| FPFNKWGKAR | 0.02 | 0.889091 | Low | High |
| KWGKARLYYD | 0.10 | 0.289722 | Low | High |
| YAISAKNRAR | 0.03 | 0.154021 | Low | High |
| AISAKNRART | 0.05 | 0.241258 | Low | High |
| KNRARTVAGV | 0.12 | 0.254056 | Low | High |
| NRQFHQKLLK | 0.14 | 0.872914 | Low | High |
| RQFHQKLLKS | 0.06 | 0.938861 | Low | High |
| RIMASLVLAR | 0.05 | 0.515705 | High | High |
| RNLQHRLYEC | 0.08 | 0.165926 | Low | Non-CPP |
| RLYECLYRNR | 0.15 | 0.219346 | Low | High |
| SLRCGACIRR | 0.10 | 0.297578 | High | High |
| RCGACIRRPF | 0.15 | 0.288701 | High | High |
| CGACIRRPFL | 0.06 | 0.282884 | High | High |
| GACIRRPFLC | 0.19 | 0.252159 | High | High |
| ACIRRPFLCC | 0.11 | 0.249754 | High | High |
| CIRRPFLCCK | 0.31 | 0.306758 | High | High |
| IRRPFLCCKC | 0.11 | 0.355792 | High | High |
| RRPFLCCKCC | 0.18 | 0.274986 | High | High |
| MSYYCKSHKP | 0.01 | 0.306949 | Low | High |
| ANTCTERLKL | 0.02 | 0.144577 | Low | High |
| SWEVGKPRPP | 0.02 | 0.577246 | Low | High |
| VGKPRPPLNR | 0.11 | 0.233226 | Low | High |
| GKPRPPLNRN | 0.16 | 0.742499 | Low | High |
| KALKYLPIDK | 0.20 | 0.613457 | Low | High |
| DKCSRIIPAR | 0.01 | 0.588037 | Low | High |
| KCSRIIPARA | 0.05 | 0.577426 | Low | High |
| CSRIIPARAR | 0.07 | 0.565072 | Low | High |
| SRIIPARARV | 0.11 | 0.783032 | Low | High |
| RIIPARARVE | 0.17 | 0.441924 | Low | High |
| SVVNARLRAK | 0.04 | 0.107521 | Low | High |
| VVNARLRAKH | 0.10 | 0.101852 | Low | High |
| VNARLRAKHY | 0.08 | 0.351672 | Low | High |
| NARLRAKHYV | 0.13 | 0.942607 | Low | High |
| PAPRTLLTKG | 0.10 | 0.701705 | Low | High |
| APRTLLTKGT | 0.02 | 0.414738 | Low | High |
| FNSVCRLMKT | 0.01 | 0.084142 | Low | Non-CPP |
| FLGTCRRCPA | 0.09 | 0.153800 | High | High |
| DNKLKAHKDK | 0.05 | 0.454919 | Low | High |
| KLKAHKDKSA | 0.22 | 0.624144 | Low | High |
| FLTRNPAWRK | 0.17 | 0.889087 | Low | High |
| RNPAWRKAVF | 0.18 | 0.548965 | Low | High |
| GIPKDMTYRR | 0.06 | 0.265085 | Low | High |
| DMTYRRLISM | 0.10 | 0.234218 | Low | Non-CPP |
| GNPKAIKCVP | 0.05 | 0.253610 | Low | High |
| WNTFTRLQSL | 0.06 | 0.961510 | Low | Non-CPP |
| ELWAKRNIKP | 0.06 | 0.982818 | Low | High |
| LWAKRNIKPV | 0.01 | 0.982818 | Low | High |
| WAKRNIKPVP | 0.17 | 0.862586 | Low | High |
| RNIKPVPEVK | 0.05 | 0.642094 | Low | High |
| LLIGLAKRFK | 0.19 | 0.367884 | High | High |
| GLAKRFKESP | 0.18 | 0.908642 | Low | High |
| KMQRMLLEKC | 0.17 | 0.500000 | High | High |
| VLRQWLPTGT | 0.00 | 0.407571 | Low | High |
| DMSKFPLKLR | 0.11 | 0.167688 | High | High |
| MSKFPLKLRG | 0.02 | 0.319169 | Low | High |
| SKFPLKLRGT | 0.09 | 0.463853 | Low | High |
| KFPLKLRGTA | 0.01 | 0.463853 | Low | High |
| MILSLLSKGR | 0.02 | 0.290394 | Low | High |
| LLSKGRLIIR | 0.08 | 0.570179 | High | High |
| GRLIIRENNR | 0.03 | 0.864554 | Low | High |
| RLIIRENNRV | 0.03 | 0.930275 | Low | High |
| ORF6 | ||||
| LIIKNLSKSL | 0.03 | 0.692987 | Low | High |
| ORF7a | ||||
| HVYQLRARSV | 0.00 | 0.333973 | Low | High |
| QLRARSVSPK | 0.18 | 0.788277 | Low | High |
| RARSVSPKLF | 0.06 | 0.540759 | Low | High |
| RSVSPKLFIR | 0.03 | 0.387766 | Low | High |
| ITLCFTLKRK | 0.00 | 0.781141 | High | High |
| TLCFTLKRKT | 0.17 | 0.809793 | Low | High |
| LCFTLKRKTE | 0.01 | 0.809793 | Low | High |
| ORF8 | ||||
| SKWYIRVGAR | 0.06 | 0.354214 | Low | High |
| KWYIRVGARK | 0.15 | 0.337595 | Low | High |
| YIRVGARKSA | 0.13 | 0.276083 | Low | High |
* Higher scores show more possibility of cell-penetrating potential.