Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Interaction between IgG Fc and the neonatal Fc receptor. a Recycling of serum IgG by pH-dependent binding with FcRn. b Complex structure of human FcRn and human IgG Fc variant (M252Y/S254T/T256E) (PDB: 4N0U). The key amino acid residues of human Fc region that highly contribute to the pH-dependent interaction with human FcRn were annotated in the crystal structure. The numbers of amino acid were denoted based on the Kabat EU numbering system
