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. 2021 Feb 19;16(2):e0247527. doi: 10.1371/journal.pone.0247527

Table 3. Adjusted rates and rate differences for age-specific trajectories of respiratory health service utilization for birth groups.

Age (in years) Birth group Adjusted Rate [95% CI] Rate difference [95% CI] Percentage of change (% [95% CI])
Birth to < 1 Reference 370.7 [367.6, 373.8] Reference
Moderate/late PTB 536.9 [524.1, 549.8] 166.2 [147.3, 185.2]* 45 [41, 47]
Very PTB 569.1 [537.1, 601.0] 198.4 [152.4, 244.3]* 54 [45, 61]
SGA at term 357.0 [347.9, 366.2] -13.7 [-27.5, 0.1] -4 [–6, 0]
LGA at term 433.1 [423.4, 442.7] 62.4 [47.9, 76.9]* 17 [14, 18]
1 to < 2 Reference 345.3 [342.3, 348.3] Reference
Moderate/late PTB 454.0 [442.2, 465.8] 108.7 [91.3, 126.2]* 31 [29, 34]
Very PTB 590.6 [558.0, 623.1] 245.3 [198.4, 292.2]* 71 [63, 79]
SGA at term 325.8 [317.1, 334.6] -19.5 [-32.7, -6.2]* - 6 [–7, –4]
LGA at term 395.2 [386.0, 404.4] 49.9 [36.0, 63.8]* 14 [13, 16]
2 to < 3 Reference 228.5 [226.0, 230.9] Reference
Moderate/late PTB 288.0 [278.6, 297.4] 59.5 [45.7, 73.4]* 26 [23, 29]
Very PTB 380.8 [355.0, 406.7] 152.3 [115.2, 189.6]* 67 [57, 76]
SGA at term 211.0 [204.0, 218.1] -17.5 [-28.1, -6.8]* - 8 [–10, –6]
LGA at term 251.9 [244.6, 259.3] 23.4 [12.3, 34.5]* 10 [8, 12]
3 to < 4 Reference 181.9 [179.8, 184.1] Reference
Moderate/late PTB 235.4 [226.9, 243.9] 53.5 [40.9, 66.0]* 29 [26, 33]
Very PTB 247.9 [227.2, 268.6] 66 [36.1, 95.8]* 36 [26, 46]
SGA at term 168.9 [162.6, 175.2] -13 [-22.6, -3.5]* - 7 [–9, –5]
LGA at term 206.5 [199.9, 213.2] 24.6 [14.6, 34.6]* 14 [11, 16]
4 to < 5 Reference 147.9 [146.0, 149.9] Reference
Moderate/late PTB 186.6 [179.0, 194.2] 38.7 [27.4, 49.8]* 26 [23, 29]
Very PTB 230.3 [210.4, 250.3] 82.4 [53.7, 111.1]* 56 [44, 67]
SGA at term 137.4 [131.7, 143.1] -10.5 [-19.2, -2.0]* - 7 [–10, –5]
LGA at term 158.2 [152.4, 164.1] 10.3 [1.5, 19.1]* 7 [4, 9]
5 to < 6 Reference 115.4 [113.7, 117.1] Reference
Moderate/late PTB 143.3 [136.7, 149.9] 27.9 [18.1, 37.7]* 24 [20, 28]
Very PTB 157.5 [141.1, 173.9] 42.1 [18.4, 65.8]* 36 [24, 49]
SGA at term 111.1 [106.0, 116.2] -4.3 [-12.0, 3.4] -4 [–7, 3]
LGA at term 133.4 [128.0, 138.7] 18 [9.9, 26.1]* 16 [12, 19]

Reference group = appropriate-for-gestational age infants born at term; CI = confidence interval; LGA = large for gestational age; PTB = preterm birth; SGA = small for gestational age.

Adjusted rates expressed as aggregated ED visits and hospitalizations for all combined respiratory conditions per 1,000 singleton live births.

* statistically significant differences (p-value < 0.05) between the corresponding adverse birth group and the reference group using Bonferroni’s correction of p-value for multiple comparisons.