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. 2021 Feb 19;7(8):eabe1122. doi: 10.1126/sciadv.abe1122

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Fig. 3 — (A to E) Differential regulation of (A) cleaved caspase 3, (B) cleaved caspase 8, (C) cleaved caspase 9, (D) cPARP, and (E) γH2AX in Jurkat cells exposed to 300 mosmol/liter NaCl by a step (black) or a 10-hour ramp (magenta). The left panel shows selected single-cell distributions over the cumulative exposure with individual lines representing independent experiments. Red line indicates the threshold for determining the ON-fraction. Right panels represent ON-fraction mean and SD of 3 to 10 independent experiments as a function of cumulative exposure of NaCl. (F) ON-fraction kinetics of caspase signaling markers over time indicate early (caspase 3 and cPARP) and late (caspase 8 and 9) activation. Lines indicate mean and SD of 3 to 10 independent experiments.