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. 2021 Feb 19;7(8):eabf0717. doi: 10.1126/sciadv.abf0717

Fig. 7. Reduced complex I methylation causes premature ageing.

Fig. 7

(A) Codependency of SLC25A26 with genes of indicated categories in cancer cell lines as Pearson’s correlation of CERES scores summarized in box plots with median, upper and lower quartile, and 1.5× interquartile range as whiskers. (B) Modification status of the unmodified/modified endogenous peptides in SAMC KO MEFs versus controls relative to standards (n = 3). Significantly changed modified peptide in black. Targets in the right box without quantifiable unmodified peptides. (C) Proteomic levels of enzymes in serine biosynthesis and SAM metabolism in 4-day-old larvae (n = 5). (D) Fly survival curve, one of two experiments shown. (E) Adjusted P values of functional categories in female i172g fly proteomes at 30 or 50 days (n = 3). Significant labels (P < 0.05) are shown. (F) Proteomic changes in i172g insects [n = 5 for larvae (L), n = 3 for flies (F)] as violin plots with median as horizontal line. Graphs show means ±/+ SD. *P < 0.05 and **P < 0.01 with Bonferroni-adjusted P values (C and E) or log-rank test (D).