Fig. 2.

Open field activity of rats was quantified by an automated program following administration of doses of m-CPP (a–c) or CBZ (d–f) that were visually observed to induced minimal motor impairment in the subjective MMI screen. a–c Administration of m-CPP induced dose-dependent suppression of all outcome measures of motor activity. ****Indicates significantly different from control, p < 0.0001. d–f Administration of a single dose of CBZ induced a robust reduction of motor activity in the open field, consistent with previous reports for this compound at a similar (33 mg/kg) dose [11]. **Indicates significantly different from control, p < 0.01; ***p < 0.001